Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic tumor that typically occurs in older adults. Patients with BPDCN usually present with solitary or multiple skin lesions. Localized or disseminated lymphadenopathy at presentation is common. A case report illustrating histopathologically proven BPDCN initially misdiagnosed as breast infiltrating ductal carcinoma in a 39-year-old woman is presented. In this case, the patient presented with a breast mass without an obvious skin lesion initially. The morphology of the tumor cells mimicked high grade breast carcinoma cells. Without complete immunohistochemical study, this case was initially misdiagnosed as infiltrating ductal carcinoma. Reviewing the previous literature about BPDCN, no case with a breast mass and an absence of characteristic skin lesions initially has been reported. The purpose for which we are discussing this case is to reduce misdiagnosis when the initial symptom is unusual.

A Case Report Blastic Plasmacytoid Dendritic Cell Neoplasm Is Misdiagnosed as Breast Infiltrating Ductal Carcinoma

Prognosis of vasculitis associated myelodysplasia.

Systemic vasculitis involving the lung is a rare manifestation of myelodysplastic syndrome (MDS), and secondary vasculitis is considered to have poor prognosis. A 44-year-old man presented with fever and dyspnea of 1 month duration. A chest radiograph revealed bilateral multiple wedge shaped consolidations. In addition, the results of a percutaneous needle biopsy for non-resolving pneumonia were compatible with pulmonary vasculitis. Bone marrow biopsy was performed due to the persistence of unexplained anemia and the patient was diagnosed with MDS. We reported a case of secondary vasculitis presenting as non-resolving pneumonia, later diagnosed as paraneoplastic syndrome of undiagnosed MDS. The cytopenia and vasculitis improved after a short course of glucocorticoid treatment, and there was no recurrence despite the progression of underlying MDS.

/pdf/pulmonary-leukocytoclastic-vasculitis-as-an-initial-1jd509gykd.pdf

Pulmonary Leukocytoclastic Vasculitis as an Initial Presentation of Myelodysplastic Syndrome.

We have read with interest the report by Laporte et n/(l9YO) in which they describe the effect of folinic acid on the expansion of the peripheral blood stem cell (PBSC) pool during haematopoietic recovery after chemotherapy. We have collected PBSC from 34 adult patients with acute leukaemia following consolidation chemotherapy. However, it was possible to obtain > 1 x loi of granulocyte/macrophage progenitor cells (CFU-GM) per kg of body weight in only 1 3 / 34 ( 38.20/,) cases during a single course of leukaepheresis consisting of four collections. For the remaining 2 1 patients, in whom the dose of CFU-GM collected was not sufficient for valid haemopoietic reconstitution, another course of leukapheresis was required to obtain sufficient CFLJGM. In patients with acute lymphoblastic leukaemia (ALL). malignant lymphoma, and solid tumours. we have employed granulocyte colony-stimulating factor (G-CSF) and > 1 x 10' CFU-CM/kg were collected in 10/14 (71.4%) cases tested during a single course of leukapheresis. Thus, the use of GCSF is a promising strategy for patients with low yields of CFU-GM. However, in patients with acute myelogenous leukaemia (AMI,) the use of G-CSF is restricted. since AML blasts have receptors for G-CSF and may be stimulated by GCSF. The report by Laporte rt ( I / ( 1 Y90) suggested the use of folinic acid for the expansion of the PBSC pool and we evaluated the effect of folinic acid on two patients with AML. Each patient underwent two courses of leukapheresis: the first leukapheresis was performed without folinic acid and the second one with folinic acid during haemopoietic recovery from intensive chemotherapy for the consolidation of complete remission. The chemotherapy regimens used were the same for the two courses of consolidation chemotherapy. Folinic acid ( 5 0 mg/d) was intravenously administered on day 1 5 from initiation of consolidation chemotherapy and continued through the leukapheresis. The numbers of CFUGM collected at the first leukapheresis were 5.6 x lO'/kg and 5.6 x I04/kg in the two patients, respectively. At the second course of leukapheresis with folinic acid, the yields of CFU-CM were 2.1 x 104/kg and 2 .4 x I04/kg, respectively. The numbers of erythroid progenitor cells (BFU-E) at the first course of leukapheresis were 1 5.0 x 1 O+/kg and 18.4 x 1 04/ kg, respectively, while the numbers a t the second leukapheresis with folinic acid were 5.0 x lO'/kg and 6.3 x 10'/kg, respectively. These data indicate that folinic acid did not result in an increase of CFU-GM and BFU-E. though the yields of CFU-GM have been reported to diminish following successive courses of chemotherapy (Reiffers et a/. 1987) . Therefore the effect of folinic acid should be evaluated in patients who achieved complete remission. In the report by Laporte et a/ (1 990) the first course of leukapheresis was performed during a recovery phase from remission induction chemotherapy while the second one was done during a recovery from consolidation chemotherapy. Since chemotherapy-induced myelosuppression is more profound after remission induction than after consolidation, it is difficult to compare the yields of PBSC under these different situations.

Folinic acid did not expand the peripheral blood stem cell pool during recovery from consolidation chemotherapy

[Refractory anaemia with an excess of myeloblasts and cutaneous vasculitis (author's transl)].

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Sobel A

Author Tools

Chat about Author

Papers

[Refractory anaemia with an excess of myeloblasts and cutaneous vasculitis (author's transl)].