So Eun Park
Ewha Womans University
8 Papers
24 Citations
So Eun Park is an academic researcher from Ewha Womans University. The author has contributed to research in topics: Topoisomerase & Catalysis. The author has an hindex of 7, co-authored 8 publications.
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Papers
Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity
TL;DR: A group of novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids was prepared and one-dose anticancer test results indicated that compounds 3a and 3g exhibited the highest ability to inhibit the proliferation of different cancer cell lines.
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A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases.
Han Byeol Kwon,Chanmi Park,Kyung Hwa Jeon,Eunyoung Lee,So Eun Park,Kyu Yeon Jun,Tara Man Kadayat,Pritam Thapa,Radha Karki,Younghwa Na,Mi Sun Park,Seung Bae Rho,Eung-Seok Lee,Youngjoo Kwon +13 more
TL;DR: The modification of compounds 8 and 22 with the introduction of a methoxy instead of a hydroxy group enhanced endogenous topo inhibitory activity, metabolic stability in diverse types of liver microsomes and improved pharmacokinetic parameters in rat plasma such as augmentation of bioavailability.
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Synthesis of benzo-annulated tryptanthrins and their biological properties.
TL;DR: Although the benzo-annulation on quinazolin-4(3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the benzonulation on indolin-3-one ring affected the inhibitors activity very much especially by linear annulation.
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Benzo[b]tryptanthrin inhibits MDR1, topoisomerase activity, and reverses adriamycin resistance in breast cancer cells.
TL;DR: Benzo[b]tryptanthrin is an indoloquinazoline alkaloid isolated from indigo as discussed by the authors, and its benzo-annulated derivative, benzo[c]tiptanthrin, inhibit both topoisomerases I (topo-I) and II (Topo-II) and cause cytotoxicity in several human cancer cell lines.
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Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor.
Kyu Yeon Jun,Hanbyeol Kwon,So Eun Park,Eunyoung Lee,Radha Karki,Pritam Thapa,Jun Ho Lee,Eung-Seok Lee,Youngjoo Kwon +8 more
TL;DR: The rationale for designing specific catalytic inhibitors of topoisomersase II (topo II) over topoisomerase I ( topo I) is described and the results were compared with other previously published dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives to explain the structure-activity relationships.
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