Smit K. Shah
Kettering University
10 Papers
49 Citations
Smit K. Shah is an academic researcher from Kettering University. The author has contributed to research in topics: Cancer & Chemistry. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of Smit K. Shah include Memorial Sloan Kettering Cancer Center.
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Papers
Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.
Tony Taldone,Pallav D. Patel,Maulik R. Patel,Hardik J. Patel,Christopher E. Evans,Anna Rodina,Stefan O. Ochiana,Smit K. Shah,Mohammad Nasir Uddin,Daniel T. Gewirth,Gabriela Chiosis +10 more
TL;DR: The methods developed here provide a blueprint for parsing out the contribution of the four HSp90 paralogues to the perceived biological activity with the current Hsp90 chemotypes and set the ground for the development of paralogue selective inhibitors.
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The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
Maria Carmen Inda,Maria Carmen Inda,Suhasini Joshi,Tai Wang,Alexander Bolaender,Srinivasa Gandu,John Koren,Alicia Yue Che,Tony Taldone,Pengrong Yan,Weilin Sun,Mohammad Nasir Uddin,Palak Panchal,Matthew Riolo,Smit K. Shah,Afsar Barlas,Ke Xu,Lon Yin L. Chan,Alexandra Gruzinova,Sarah Kishinevsky,Lorenz Studer,Valentina Fossati,Scott Noggle,Julie R. White,Elisa de Stanchina,Sonia Sequeira,Kyle H. Anthoney,John W. Steele,Katia Manova-Todorova,Sujata Patil,Mark Dunphy,Nagavarakishore Pillarsetty,Ana C. Pereira,Ana C. Pereira,Hediye Erdjument-Bromage,Thomas A. Neubert,Anna Rodina,Stephen D. Ginsberg,Stephen D. Ginsberg,Natalia V. De Marco García,Wenjie Luo,Gabriela Chiosis +41 more
TL;DR: This work uses cellular and animal models as well as human biospecimens to show that AD-related stressors mediate global disturbances in dynamic intra- and inter-neuronal networks through pathologic rewiring of the chaperome system into epichaperomes.
Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94
Hardik J. Patel,Pallav D. Patel,Pallav D. Patel,Stefan O. Ochiana,Pengrong Yan,Weilin Sun,Maulik R. Patel,Smit K. Shah,Elisa Tramentozzi,James C. Brooks,Alexander Bolaender,Liza Shrestha,Ralph Stephani,Paola Finotti,Cynthia A. Leifer,Zihai Li,Daniel T. Gewirth,Tony Taldone,Gabriela Chiosis +18 more
TL;DR: It is shown that 18c has biological activity in several cellular models of inflammation and cancer and is present here for the first time the in vivo profile of a Grp94 inhibitor.
Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma.
Srikanth R. Ambati,Eloisi Caldas Lopes,Kohji Kosugi,Ullas Mony,Ahmet Zehir,Smit K. Shah,Tony Taldone,Andre L. Moreira,Paul A. Meyers,Gabriela Chiosis,Malcolm A.S. Moore +10 more
TL;DR: The results indicated that Ewing sarcoma tumor growth and the metastatic burden were significantly reduced in the mice injected with PU‐H71 compared to the control mice, providing a strong rationale for clinical evaluation of PU‐h71 alone and in combination with bortezomib in Ewing Sarcoma.
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HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
Sarah Kishinevsky,Tai Wang,Anna Rodina,Sun Young Chung,Chao Xu,John Philip,Tony Taldone,Suhasini Joshi,Mary L. Alpaugh,Mary L. Alpaugh,Alexander Bolaender,Simon Gutbier,Davinder Sandhu,Faranak Fattahi,Bastian Zimmer,Smit K. Shah,Elizabeth Chang,Carmen Inda,Carmen Inda,John Koren,John Koren,Nathalie Saurat,Marcel Leist,Steven S. Gross,Venkatraman E. Seshan,Christine Klein,Mark J. Tomishima,Hediye Erdjument-Bromage,Thomas A. Neubert,Ronald C. Henrickson,Gabriela Chiosis,Lorenz Studer +31 more
TL;DR: It is shown that events triggered by PD-related genetic or toxic stimuli alter the neuronal proteome, thereby altering the stress-specific chaperome networks, which produce changes detected by chemical sensors.