Sloan Ayers
Bristol-Myers Squibb
43 Papers
175 Citations
Sloan Ayers is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 16, co-authored 37 publications. Previous affiliations of Sloan Ayers include Merck & Co. & University of the Free State.
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Papers
Resorcylic Acid Lactones with Cytotoxic and NF-κB Inhibitory Activities and Their Structure–Activity Relationships
Sloan Ayers,Tyler N. Graf,Audrey F. Adcock,David J. Kroll,Susan Matthew,Esperanza J. Carcache de Blanco,Qi Shen,Steven M. Swanson,Mansukh C. Wani,Cedric J. Pearce,Nicholas H. Oberlies +10 more
TL;DR: In the latter assay, compounds 1 and 5 displayed sub-micromolar activities that were on par with the positive control, and as such, these compounds may serve as a lead scaffold for future medicinal chemistry studies.
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Flavones from Struthiola argentea with anthelmintic activity in vitro
Sloan Ayers,Deborah L. Zink,Kenneth Mohn,Joanne S. Powell,Christine M. Brown,Terry Murphy,Robert Brand,Seef Pretorius,Dennis W. Stevenson,Donald Thompson,Sheo B. Singh +10 more
TL;DR: Bioassay-guided isolation of three anthelmintic flavones 1-3, including the flavone, 5,6,2',5',6'-pentamethoxy-3',4'-methylenedioxyflavone (3) from the methanol extract of Struthiola argentea (Thymelaeaceae) is reported.
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Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae
Mario Figueroa,Tyler N. Graf,Sloan Ayers,Audrey F. Adcock,David J. Kroll,Jilai Yang,Steven M. Swanson,Ulyana Muñoz-Acuña,Esperanza J. Carcache de Blanco,Rajesh Agrawal,Mansukh C. Wani,Blaise A. Darveaux,Cedric J. Pearce,Nicholas H. Oberlies +13 more
TL;DR: Bioactivity-directed fractionation of the organic extracts of two filamentous fungi of the Bionectriaceae, strains MSX 64546 and MSX 59553 from the Mycosynthetix library, led to the isolation of a new dimeric epipolythiodioxopiperazine alkaloid, verticillin H, along with six related analogs.
Production of Hygromycin A Analogs in Streptomyces hygroscopicus NRRL 2388 through Identification and Manipulation of the Biosynthetic Gene Cluster
TL;DR: The predicted Hyg26 protein has sequence homology to short-chain alcohol dehydrogenases and is assigned to the final step in production of the 5-dehydro-alpha-L-fucofuranose, catalyzing the reduction of alpha-L
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Anthelmintic activity of aporphine alkaloids from Cissampelos capensis.
Sloan Ayers,Deborah L. Zink,Kenneth Mohn,Joanne S. Powell,Christine M. Brown,Terry Murphy,Robert F. Brand,Seef Pretorius,Dennis W. Stevenson,Donald Thompson,Sheo B. Singh +10 more
TL;DR: Two known aporphine alkaloids, (S)-dicentrine (1) and (S-neolitsine (2), have been isolated from the MeOH extract of the aerial parts of Cissampelos capensis (Menispermaceae).
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