Sivakumar Loganathan
University of Chicago
15 Papers
60 Citations
Sivakumar Loganathan is an academic researcher from University of Chicago. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 8, co-authored 15 publications. Previous affiliations of Sivakumar Loganathan include University of Pittsburgh & Periyar University.
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Papers
Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer
Soundararajan Krishnaswamy,Rajani Kanteti,Jonathan S. Duke-Cohan,Sivakumar Loganathan,Wanqing Liu,Patrick C. Ma,Martin Sattler,Patrick A. Singleton,Nithya Ramnath,Federico Innocenti,Dan L. Nicolae,Zheng Ouyang,Jie Liang,John D. Minna,Mark Kozloff,Mark K. Ferguson,Viswanathan Natarajan,Yi Ching Wang,Joe G.N. Garcia,Everett E. Vokes,Ravi Salgia +20 more
TL;DR: The most frequent mutation of MET, MET-N375S, seems to confer resistance to MET inhibition based on hepatocyte growth factor ligand binding, molecular modeling, and apoptotic susceptibility to MET inhibitor studies.
194
Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion
Ramasamy Jagadeeswaran,Hanna Surawska,Soundararajan Krishnaswamy,Varalakshmi Janamanchi,A. Craig Mackinnon,Tanguy Y. Seiwert,Sivakumar Loganathan,Rajani Kanteti,Trevor W. Reichman,Vidya Nallasura,Stuart Schwartz,Leonardo Faoro,Yi Ching Wang,Luc Girard,Maria Tretiakova,Salman Ahmed,Osvaldo Zumba,Lioubov Soulii,Vytas P. Bindokas,Livia Szeto,Gavin J. Gordon,Raphael Bueno,David J. Sugarbaker,Mark W. Lingen,Martin Sattler,Thomas Krausz,Wickii T. Vigneswaran,Viswanathan Natarajan,John D. Minna,Everett E. Vokes,Mark K. Ferguson,Aliya N. Husain,Ravi Salgia +32 more
TL;DR: An important role for paxillin in lung cancer is established as a target of a number of oncogenes involved in key signal transduction and important in cell motility and migration.
128
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription.
Rajani Kanteti,Vidya Nallasura,Sivakumar Loganathan,Maria Tretiakova,Todd G. Kroll,Soundararajan Krishnaswamy,Leonardo Faoro,Philip T. Cagle,Aliya N. Husain,Everett E. Vokes,Deborah Lang,Ravi Salgia +11 more
TL;DR: The frequency as well as the average intensity of the expression of PAX5 increased from pulmonary carcinoid to large-cell neuroendocrine carcinoma, and it is proposed that PAX5 could be an important regulator of c-Met transcription and a potential target for therapy in SCLC.
107
Benzyl Isothiocyanate-Induced DNA Damage Causes G2/M Cell Cycle Arrest and Apoptosis in Human Pancreatic Cancer Cells
TL;DR: The results of this study suggest the involvement of multiple signaling pathways targeted by BITC in mediating G2/M cell cycle arrest and apoptosis in Capan-2 cells and warrant further investigation.
104
Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.
Sivakumar Loganathan,Prabodh K. Kandala,Parul Gupta,Sanjay K. Srivastava,Sanjay K. Srivastava +4 more
TL;DR: The study suggests that phenethyl isothiocyanate could be used alone or in combination with other therapeutic agents to treat ovarian cancer and suggests that PEITC targets EGFR/AKT pathway in the authors' model.