Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung

Preoperative embolization in spinal and pelvic metastases.

OBJECTIVE. The purpose of this study was to evaluate, in relation to intraoperative estimated blood loss (EBL), the effectiveness of preoperative transcatheter arterial embolization of hypervascular osseous metastatic lesions before orthopedic resection and stabilization.MATERIALS AND METHODS. Between June 1987 and November 2007, 22 patients underwent transcatheter arterial embolization of tumors of the long bone, hip, or vertebrae before resection and stabilization. Osseous metastatic lesions from renal cell carcinoma, malignant melanoma, leiomyosarcoma, and prostate cancer were embolized. All patients were treated with a coaxial catheter technique with polyvinyl alcohol (PVA) particles alone or a combination of PVA particles and coils. After embolization, each tumor was angiographically graded according to devascularization (grades 1–3) based on tumor blush after contrast injection into the main tumor-feeding arteries.RESULTS. In patients with complete devascularization (grade 1), mean EBL was calculate...

Interventional Management of Hypervascular Osseous Metastasis: Role of Embolotherapy Before Orthopedic Tumor Resection and Bone Stabilization

Transarterial embolization of primary and secondary tumors of the skeletal system.

Surgery of long bone metastases is associated with a significant risk of perioperative blood loss, which may necessitate blood transfusion. Successful embolization (> 70% obliteration of vascularit...

/pdf/preoperative-embolization-in-surgical-treatment-of-long-bone-1kdms3ad1l.pdf

Preoperative embolization in surgical treatment of long bone metastasis: a systematic literature review

Eighteen patients (11 renal tumours, 3 bronchogenic carcinomas, 4 others) with 24 different bone metastases were embolized for preoperative devascularization (11 x) or for intractable pain (7 x). Metastases were localized in the spine (17 x), pelvis (5 x), and shoulder girdle (2 x). All metastases were hypervascularized. Post-embolization showed no complications. Intraoperative blood loss was minimized to 2100 ml (600 ml-4200 ml). Pain relief was achieved in 6 out of 7 patients. Eight of 18 patients died as a result of underlying diseases (follow-up 7 months).

Embolization of bone metastases

Forty-two patients with locally advanced breast cancer (n = 8) or recurrent breast cancer (n = 34) received regional chemotherapy (mitoxantrone 25 mg/m2 per 24 h) via the internal mammary artery or other vessels of the subclavian artery. To prevent artery thrombosis 500-1000 U heparin per hour were administered i.v. Tumour perfusion was monitored by intra-arterial angio-CT. Remission rates (CR + PR) were 100% (primary breast cancer) and 89% (recurrent tumours), respectively. Intra-arterial chemotherapy was well tolerated. No complications were noted.

[Superselective intra-arterial chemotherapy in breast cancer].

[Side effects and complications of intra-arterial tumor therapy--experiences with 577 interventions].

PURPOSE Evaluation of intraarterial cancer treatment in recurrent pelvic tumors, which were resistent to other treatment modalities. PATIENTS AND METHODS Ninety-seven patients suffering from pelvic recurrences originating from bladder (n = 40), rectum (n = 19), cervix (n = 21) oder other organs (n = 17) were treated by intraarterial chemotherapy (111 times) or transcatheter embolisation (52 times). RESULTS Less than 20% of our patients had remission of the tumor burden but tumor symptoms (especially pain and bleeding) could be controlled in 35 to 87% of the patients. The main complication was a muscle necrosis after intraarterial chemotherapy because of recurrent bladder cancer. CONCLUSION Intraarterial cancertherapy is a useful procedure for symptomatic treatment of tumor symptoms especially in case of bleeding. Local tumor control can only be achived in a minority of the patients.

[Intra-arterial treatment of therapy-resistant residual tumors of the pelvis].

PURPOSE: To evaluate the effectiveness of intraarterial infusion chemotherapy (IAC) with mitoxantrone hydrochloride in patients with previously treated, locally recurrent breast cancer. MATERIALS AND METHODS: Thirty-nine women (aged 31-82 years) with recurrent breast cancer underwent superselective IAC (25 mg/m2 mitoxantrone hydrochloride every 24 hours) through the subclavian artery branches after heparin administration. The extent of tumor perfusion was monitored with computed tomography during the intraarterial administration of contrast medium. IAC was repeated one to nine times. Patients had previously undergone radiation therapy (n = 39), surgery (n = 20), or systemic chemotherapy (n = 23). RESULTS: The overall response rate was 77% (n = 30). Eight patients had complete remission. Progression occurred in three patients. Remission was observed in cases of lymph node involvement (n = 9). Seven patients are still undergoing treatment. Side effects were usually moderate. Nine patients died of systemic t...

Previously treated, locally recurrent breast cancer: treatment with superselective intraarterial chemotherapy.

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