PCB 118 induces ultrastructural alterations in the rat liver.

Liver alterations were stereologically determined in five groups, each of 10 male and female Sprague–Dawley weanling rats fed PCB 105 (2,3,3′,4,4′-pentachlorobiphenyl) for 13 weeks at concentrations of 0.05, 0.5, 5, and 50 ppm mixed with corn oil. Animals from two groups receiving the oil in diets served as controls for each gender. A significant increase in mean volume fraction (VF) of smooth endoplasmic reticulum (SER) profiles was estimated in hepatocytes of female rats in 0.5, 5, and 50 ppm groups. A significant decrease in VF of mitochondria in female rats at 50 ppm was detected. In addition, a decrease in VF of lipid droplets was measured in female rats at 0.5, 5, and 50 ppm groups. No difference was found in VF of rough endoplasmic reticulum (RER) cisternae, and peroxisome profiles at any concentration of the PCB in either male or female animals as compared to baseline values from controls. A significant elevation of baseline VF for RER in female rats was detected in comparison with males. In the p...

PCB 105-induced ultrastructural alterations in the rat liver: A stereological study

Toxic Effects and Mode of Action
Mechanism of Action
Toxicokinetics and Metabolism
Absorption, distribution and elimination
Metabolism


Effects in Humans
Single exposures
Repeated exposure
Local effects on skin and mucous membranes
Allergenic effects
Reproductive and developmental toxicity
Genotoxicity
Carcinogenicity


Animal Experiments and in vitro Studies
Acute toxicity
Subacute, subchronic and chronic toxicity
Local effects on skin and mucous membranes
Allergenic effects
Reproductive and developmental toxicity
Genotoxicity
Carcinogenicity


Manifesto (MAK value/classification)


Keywords:

chlorinated biphenyls;
PCB;
polychlorinated biphenyls;
mechanism of action;
toxicokinetics;
metabolism;
(sub)acute toxicity;
(sub)chronic toxicity;
irritation;
reproductive toxicity;
fertility;
developmental toxicity;
genotoxicity;
carcinogenicity;
occupational exposure;
maximum workplace concentration;
MAK value;
toxicity;
hazardous substance

https://onlinelibrary.wiley.com/doi/pdf/10.1002/3527600418.mb0cbphpcbe5515

Chlorinated Biphenyls [MAK Value Documentation, 2013]

146. Polychlorinated biphenyls (PCBs)

/pdf/the-nordic-expert-group-for-criteria-documentation-of-health-3t18o1lmp5.pdf

The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 146. Polychlorinated biphenyls (PCBs)

PCB 128 (2,2',3,3',4,4'-hexachlorobiphenyl) prepared in 4% corn oil and mixed in diets was given to weanling Sprague-Dawley rats. The animals were placed in eight groups, each comprising 10 males or 10 females; each group received a diet that contained 0.05, 0.5 or 5 ppm PCB. Ten animals of each gender that served as the controls were given diets mixed with only corn oil. Thirteen weeks after the commencement of dosing, animals were euthanized and liver specimens were harvested and prepared for transmission electron microscopy. The architecture of the liver parenchymal cell was indistinguishable in the animals of the lowest concentration group from those in the controls. However, smooth endoplasmic reticulum profiles increased, and abnormal mitochondria were noted in the liver of rats, regardless of gender, from 0.5 and 5 ppm groups. Based on our previous work, PCB 128 is estimated to be equally toxic as PCB 153, another di-ortho substituted PCB congener.

PCB 128-induced ultrastructural lesions in the rat liver.

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PCB 128-induced ultrastructural lesions in the rat liver.