Sinead E. Keating
Trinity College, Dublin
16 Papers
1 Citations
Sinead E. Keating is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Biology & Innate immune system. The author has an hindex of 10, co-authored 15 publications.
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Papers
IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner,Sinead E. Keating,Marcin Baran,Kristy A. Horan,Søren B. Jensen,Søren B. Jensen,Shrutie Sharma,Cherilyn M. Sirois,Tengchuan Jin,Eicke Latz,Eicke Latz,T. Sam Xiao,Katherine A. Fitzgerald,Søren R. Paludan,Andrew G. Bowie +14 more
TL;DR: IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).
mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function
Raymond P. Donnelly,Róisín M. Loftus,Sinead E. Keating,Kevin T. Liou,Christine A. Biron,Clair M. Gardiner,David K. Finlay +6 more
TL;DR: The data reveal that NK cells undergo dramatic metabolic reprogramming upon activation, upregulating rates of glucose uptake and glycolysis, and that mTORC1 activity is essential for attaining this elevatedglycolytic state.
Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells
Sinead E. Keating,Vanessa Zaiatz-Bittencourt,Róisín M. Loftus,C Keane,Kiva Brennan,David K. Finlay,Clair M. Gardiner +6 more
TL;DR: The metabolic changes that occur in peripheral blood NK cells in response to cytokine are defined to be more metabolically active than CD56dim cells, which supports their production of large amounts of IFN-γ during an immune response.
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Cytosolic DNA sensors regulating type I interferon induction
TL;DR: The nature of these DNA sensors, which include a new family of pattern recognition receptors termed the AIM2-like receptors, are reviewed and the implications of their discovery for understanding emerging principles of innate immune DNA sensing are considered.
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The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-β and in the Cortex of Aged Rats
Riffat Tanveer,Aoife Gowran,Janis Noonan,Sinead E. Keating,Andrew G. Bowie,Veronica A. Campbell +5 more
TL;DR: AEA has the proclivity to enhance Notch-1 signaling in an in vitro model of AD, which may have relevance for restoring neurogenesis and cognition in AD.
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