Sine Larsen
University of Copenhagen
287 Papers
2.1K Citations
Sine Larsen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Crystal structure & Chemistry. The author has an hindex of 38, co-authored 287 publications. Previous affiliations of Sine Larsen include European Synchrotron Radiation Facility & European Bioinformatics Institute.
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Papers
High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline
Antonia Beteva,Florent Cipriani,Stephen Cusack,Solange Delagenière,José Gabadinho,Elspeth Gordon,Matias Guijarro,David R. Hall,Sine Larsen,L. Launer,C.B. Lavault,Gordon A. Leonard,Trevor Mairs,Andrew A. McCarthy,J. E. McCarthy,Jens Meyer,Edward P. Mitchell,Stephanie Monaco,Didier Nurizzo,Petra Pernot,R. Pieritz,R.G.B. Ravelli,Vicente Rey,William Shepard,Darren Spruce,David I. Stuart,Olof Svensson,Pascal Theveneau,X. Thibault,Johan P. Turkenburg,Martin A. Walsh,Sean McSweeney +31 more
TL;DR: An automatic data-collection system has been implemented and installed on seven insertion-device beamlines and a bending-magnet beamline at the ESRF as part of the SPINE (Structural Proteomics In Europe) development of an automated structure-determination pipeline.
Structure of the bifunctional dCTP deaminase-dUTPase from Methanocaldococcus jannaschii and its relation to other homotrimeric dUTPases.
TL;DR: The bifunctional d CTP deaminase-dUTPase (DCD-DUT) from Methanocaldococcus jannaschii catalyzes the deamination of the cytosine moiety in dCTP and the hydrolysis of the triphosphate moiety forming dUMP, thereby preventing uracil from being incorporated into DNA.
Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4☆
Michael A. McDonough,Renuka Kadirvelraj,Pernille Harris,Jens-Christian N. Poulsen,Sine Larsen,Sine Larsen +5 more
TL;DR: The three‐dimensional structure of RG‐lyase from Aspergillus aculeatus has been determined to 1.5 Å resolution representing the first known structure from polysaccharide lyase family 4 and of an enzyme with this catalytic specificity.
The Structure of Endo-Beta-1,4-Galactanase from Bacillus Licheniformis in Complex with Two Oligosaccharide Products
Carsten Ryttersgaard,Jérôme Le Nours,Leila Lo Leggio,Christel Thea Jørgensen,Lars Lehmann Hylling Christensen,Mads Eskelund Bjørnvad,Sine Larsen,Sine Larsen +7 more
TL;DR: A comparison of the pattern of galactan and galactooligosaccharides degradation by AAGAL and BLGAL shows that, although both are most active on substrates with a high degree of polymerization, AAGal can degrade galactotriose and galACTotetraose efficiently, whereasBLGAL prefers longer oligosacCharides and cannot hydrolyze galactOTriose to any appreciable extent.
Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities
TL;DR: In this paper, the crystal structures of two polymorphic forms of tolfenamic acid have been determined by X-ray diffraction methods and it was shown that the yellow form is the stable low temperature modification.