https://www.kidney-international.org/article/S0085-2538(15)34232-0/pdf

Cyclosporine a induced remission of relapsing nephrotic syndrome in children

Cyclosporin A (Cs A) exerted a dose-related inhibitory effect on antigen (ovalbumin, OVA) and phytohaemagglutinin (PHA)-induced transformation of guinea-pig lymph node cells (LNC). Whereas 0.05 micrograms/ml was sufficient to depress these responses markedly, it required 100-fold this concentration of Cs A to inhibit the production of lymphocyte activating factor (LAF) by lipopolysaccharide (LPS) stimulated peritoneal macrophages. Addition of Cs A together with insoluble concanavalin A (iCon A) to LNC cultures resulted in suppressed lymphokine production, as assessed by measurement of migration inhibition factor (MIF), the generation of macrophage procoagulant activity (MPCA) and the release of lymphocyte-derived-macrophage chemotactic factor (LDCF). Cs A also inhibited MIF and procoagulant production by sensitized peritoneal exudate cells in response to antigen, at the same concentrations which blocked lymphocyte transformation. In contrast, Cs A had no direct effect on the migration of peritoneal cells from capillary tubes, or on the responses of macrophages to preformed MIF, the lymphokine inducing MPCA or LDCF. Overnight incubation of macrophages with Cs A did, however, result in mild inhibition of their basal level of procoagulant activity.

Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines.

Cyclosporine-induced remission of relapsing nephrotic syndrome in children.

Since the first human kidney allografts were performed by Hume (Hume et al. ] 952). a wide search has been made for ways to control the immune response to protect foreign grafts from rejection. With the advent of Azathioprine (Calne 1961) and its subsequent combination with steroids (Starzl et al. 1963) kidney transplantation has become a viable and economically attractive therapy for renal failure. While the results achieved with Azathioprine and steroids are, in practice, far better than could reasonably be expected on theoretical grounds, rejection still remains the greatest single cause of graft loss, with half of the transplanted kidneys failing within I year (Human Renal Transplant Registry 1977). Furthermore, those patients with successful grafts often suffer severely from the side-effects of the immunosuppressive regime (Calne 1979). Thus there is a real need for a safer, more efficient means of controlling the immune system. In the years since the advent of Azathioprine, there have been very few clinically applicable advances in this field. One of these few is the recent introduction of an entirely new immunosuppressive drug called Cyclosporin A.

The Use of Cyclosporin A Immunosuppression in Organ Grafting

Immunosuppression by cyclosporin A of experimental allergic encephalomyelitis.

Mechanisms of immunosuppression by cyclosporin.

Inhibition of the donor-specific immune response by cyclosporin-A following renal transplantation.

Pretransplant immunologic reactivity to donor lymphocytes--lack of correlation with posttransplant events.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Sinclair Nr

Author Tools

Chat about Author

Papers

Mechanisms of immunosuppression by cyclosporin.

Inhibition of the donor-specific immune response by cyclosporin-A following renal transplantation.

Pretransplant immunologic reactivity to donor lymphocytes--lack of correlation with posttransplant events.