Simone Weber
8 Papers
18 Citations
Simone Weber is an academic researcher. The author has contributed to research in topics: Erg & BAALC. The author has an hindex of 4, co-authored 8 publications.
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Papers
BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia
Simone Weber,Tamara Alpermann,Frank Dicker,Sabine Jeromin,Niroshan Nadarajah,Christiane Eder,Annette Fasan,Alexander Kohlmann,Manja Meggendorfer,Claudia Haferlach,W Kern,Torsten Haferlach,Susanne Schnittger +12 more
TL;DR: The utility of BAALC expression as a marker for prognostic risk stratification and detection of residual disease in CN-AML is underline, with an independent adverse prognostic impact on overall survival and event-free survival and on OS when eliminating the effect of allogeneic stem cell transplantation (SCT).
Gain of chromosome 21 or amplification of chromosome arm 21q is one mechanism for increased ERG expression in acute myeloid leukemia.
Simone Weber,Claudia Haferlach,Sabine Jeromin,Niroshan Nadarajah,Frank Dicker,Louisa Noel,Melanie Zenger,Tamara Alpermann,Wolfgang Kern,Torsten Haferlach,Susanne Schnittger +10 more
TL;DR: The results suggest that acquired gain of chromosome 21 or amplification of chromosome arm 21q is one mechanism contributing to increased ERG expression in AML.
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Comprehensive study on ERG gene expression in normal karyotype acute myeloid leukemia: ERG expression is of limited prognostic value, whereas the accumulation of adverse prognostic markers stepwise worsens the prognosis.
TL;DR: ERG expression is of limited prognostic value, whereas the accumulation of adverse prognostic markers stepwise worsens the prognosis.
Characterization and Quantification Of Rare BCR-ABL1 Fusion Transcripts
Susanne Schnittger,Frank Dicker,Tamara Alpermann,Christiane Eder,Annette Fasan,Simone Weber,Sabine Jeromin,Manja Meggendorfer,Wolfgang Kern,Torsten Haferlach,Claudia Haferlach +10 more
TL;DR: A detailed molecular characterization of the BCR-ABL1 rearrangement was performed and rare fusion types were detected, including one case with an additional alternative splicing event that leads to an e13a2 fusion with 19 bp insertion.
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Gene Amplifications In 84 Patients With Acute Myeloid Leukemia and 31 Patients With Myelodysplastic Syndrome Investigated By Array CGH
Andreas Roller,Simone Weber,Alexander Kohlmann,Melanie Zenger,Marita Staller,Wolfgang Kern,Susanne Schnittger,Torsten Haferlach,Claudia Haferlach +8 more
TL;DR: Characterize AML and MDS cases with gene amplifications with respect to size, affected genes and accompanying chromosomal abnormalities as well as TP53 status and detected a significantly higher number of amplified regions as compared to non-complex karyotypes.
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