Simone Simler
French Institute of Health and Medical Research
7 Papers
241 Citations
Simone Simler is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Epilepsy & Piriform cortex. The author has an hindex of 7, co-authored 7 publications.
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Papers
Opposite effects of GABAB receptor antagonists on absences and convulsive seizures.
TL;DR: In Wistar rats with spontaneous non-convulsive absence epilepsy, absence seizures were dose dependently suppressed by intraperitoneal administration of the GABAB receptor antagonists, and by bilateral microinjections into the lateral nuclei of the thalamus.
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C-fos expression after single and kindled audiogenic seizures in Wistar rats.
TL;DR: In naive Wistar rats susceptible to sound, a single audiogenic seizure induced the expression of c-fos in the subcortical auditory nuclei whereas the forebrain was almost completely devoid of any labelling, confirming that audiogenic seizures are brain-stem seizures related to dysfunction of auditory pathways.
80
Selective Susceptibility to Inhibitors of GABA Synthesis and Antagonists of GABAA Receptor in Rats with Genetic Absence Epilepsy
TL;DR: An abnormal cortical GABAergic activity may underlie absence seizures in GAERS, a selected strain of Wistar rats that occur spontaneously in genetic absence epilepsy rats from Strasbourg.
43
BDNF Restores the Expression of Jun and Fos Inducible Transcription Factors in the Rat Brain Following Repetitive Electroconvulsive Seizures
T.F. Hsieh,Simone Simler,M. Vergnes,Peter Gass,Christian Marescaux,Stanley J. Wiegand,Manfred Zimmermann,Thomas Herdegen,Thomas Herdegen +8 more
TL;DR: It is demonstrated thatetitive pathophysiological excitation decreases the transcriptional actions of neurons over days in the adult brain, and this decrement can be prevented by BDNF restoring the neuroplasticity at the level of gene transcription.
28
The amygdala is critical for seizure propagation from brainstem to forebrain
E. C. Hirsch,L. Danober,Simone Simler,A. Pereira de Vasconcelos,B Maton,Astrid Nehlig,Christian Marescaux,M. Vergnes +7 more
TL;DR: A critical role for the amygdala is indicated in the spread of audiogenic seizures from brainstem to forebrain, suggesting that repetition of brainstem seizures causes a propagation of the epileptic discharge toward the forebrain.