Simone Schuhler
French Institute of Health and Medical Research
13 Papers
47 Citations
Simone Schuhler is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Thrombin & Platelet activation. The author has an hindex of 9, co-authored 13 publications. Previous affiliations of Simone Schuhler include Centre national de la recherche scientifique.
Chat about Author
Papers
Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation.
Sylvie Moog,Pierre Mangin,Nadège Lenain,Catherine Strassel,Catherine Ravanat,Simone Schuhler,Monique Freund,Martine Santer,Mark L. Kahn,Bernhard Nieswandt,Christian Gachet,Jean-Pierre Cazenave,François Lanza +12 more
TL;DR: GPV binds to collagen and appears to be required for normal platelet responses to this agonist, as demonstrated in aggregation and surface plasmon resonance studies.
133
Gene Cloning of Rat and Mouse Platelet Glycoprotein V: Identification of Megakaryocyte-Specific Promoters and Demonstration of Functional Thrombin Cleavage
Catherine Ravanat,Catherine Ravanat,Martine Morales,Martine Morales,David O. Azorsa,David O. Azorsa,Sylvie Moog,Sylvie Moog,Simone Schuhler,Simone Schuhler,Pierre Grunert,Pierre Grunert,Damarys Loew,Damarys Loew,Alain Van Dorsselaer,Alain Van Dorsselaer,Jean-Pierre Cazenave,Jean-Pierre Cazenave,François Lanza,François Lanza +19 more
TL;DR: Knowing of these rodent GPV genes and availability of species-specific peptides and antibodies will be essential to further studies aiming to define the exact in vivo function of platelet GPV using animal models of thrombosis and gene inactivation experiments.
41
Screening of protein S deficiency using a functional assay in patients with venous and arterial thrombosis.
Marie-Louise Wiesel,Jean-Luc Charmantier,Jean-Marie Freyssinet,Lelia Grunebaum,Simone Schuhler,Jean-Pierre Cazenave +5 more
TL;DR: A functional assay for free protein S based on its ability to promote the prolongation of clotting time following factor Va inactivation by activated protein C when coagulation is triggered by factor Xa has allowed the detection of 34 cases of protein S deficiency, confirmed by immunological assays, and their classification.
24
Activation of human protein C by blood coagulation factor Xa in the presence of anionic phospholipids. Enhancement by sulphated polysaccharides.
J M Freyssinet,M L Wiesel,Lelia Grunebaum,J M Pereillo,J Gauchy,Simone Schuhler,G Freund,Jean-Pierre Cazenave +7 more
TL;DR: The results suggest that human factor Xa, at physiological concentrations, could activate human protein C in the presence of anionic phospholipids and that this activation could be potentiated by therapeutic concentrations of sulphated polysaccharides.
Interference of blood-coagulation vitamin K-dependent proteins in the activation of human protein C. Involvement of the 4-carboxyglutamic acid domain in two distinct interactions with the thrombin-thrombomodulin complex and with phospholipids.
TL;DR: The results suggest that the 4-carboxyglutamic acid domain of vitamin K-dependent proteins can act as a modulator of the protein C anticoagulant pathway through two distinct types of interaction.
13