Simone Keck
Max Planck Society
8 Papers
45 Citations
Simone Keck is an academic researcher from Max Planck Society. The author has contributed to research in topics: TLR4 & Signal transduction. The author has an hindex of 8, co-authored 8 publications.
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Papers
CD14 is required for MyD88-independent LPS signaling
Zhengfan Jiang,Philippe Georgel,Xin Du,Louis Shamel,Sosathya Sovath,Suzanne Mudd,Michael Huber,Christoph Kalis,Simone Keck,Chris Galanos,Marina A. Freudenberg,Bruce Beutler +11 more
TL;DR: The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective responses to microbial inducers, and the data suggest that the TLR4–MD-2 complex distinguishes LPS chemotypes, but CD14 nullifies this distinction.
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Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
Marc Schmidt,Badrinarayanan Raghavan,Badrinarayanan Raghavan,Verena Müller,Verena Müller,Thomas Vogl,György Fejer,Sandrine Tchaptchet,Simone Keck,Christoph Kalis,Peter J. Nielsen,Chris Galanos,Johannes Roth,Arne Skerra,Stefan F. Martin,Marina A. Freudenberg,Matthias Goebeler,Matthias Goebeler +17 more
TL;DR: It is shown that Ni2+ triggered an inflammatory response by directly activating human Toll-like receptor 4 (TLR4), which implicate site-specific human TLR4 inhibition as a potential strategy for therapeutic intervention in CHS that would not affect vital immune responses.
588
Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells.
Carolin N. Zorn,Simone Keck,Rudi W. Hendriks,Michael Leitges,Marina A. Freudenberg,Michael Huber +5 more
TL;DR: The study reveals that Btk is dispensable for TLR signaling and function in murine BMMCs and Interestingly, PKC-beta deficiency has also no negative effect on LPS-induced cytokine secretion, suggesting that proteins of the calcium signalosome are not involved in TLR-mediated BMMC activation.
45
R-form LPS, the master key to the activation of TLR4/MD-2-positive cells
Michael Huber,Christoph Kalis,Simone Keck,Zhengfan Jiang,Philippe Georgel,Xin Du,Louis Shamel,Sosathya Sovath,Suzanne Mudd,Bruce Beutler,Chris Galanos,Marina A. Freudenberg +11 more
TL;DR: The R‐form LPS constitutes ubiquitously part of the total LPS present in all wild‐type bacteria its contribution to the innate immune response and pathophysiology of infection is much higher than anticipated during the last half century.
Absence of TRIF Signaling in Lipopolysaccharide-Stimulated Murine Mast Cells
Simone Keck,Ines Müller,György Fejer,Iva Savic,Sandrine Tchaptchet,Peter J. Nielsen,Chris Galanos,Michael Huber,Marina A. Freudenberg +8 more
TL;DR: It is shown how the response to the same microbial ligand using the same receptor can be regulated in different cell types of the innate immune system, including bone marrow-derived mast cells and BMMCs.