Simone Finetti
University of Ferrara
7 Papers
60 Citations
Simone Finetti is an academic researcher from University of Ferrara. The author has contributed to research in topics: Glutamate receptor & Neurotensin. The author has an hindex of 6, co-authored 7 publications.
Chat about Author
Papers
Prenatal Exposure to the CB1 Receptor Agonist WIN 55,212-2 Causes Learning Disruption Associated with Impaired Cortical NMDA Receptor Function and Emotional Reactivity Changes in Rat Offspring
Tiziana Antonelli,Maria Cristina Tomasini,Maria Tattoli,Tommaso Cassano,Sergio Tanganelli,Simone Finetti,Elisa Mazzoni,Luigia Trabace,Luca Steardo,Vincenzo Cuomo,Luca Ferraro +10 more
TL;DR: Evidence is provided for a deficit in cortical glutamatergic neurotransmission and behaviour in the rat neonate following prenatal exposure to WIN and it is suggested that the reduction in cortical glutamate levels, NMDA receptor activity and alterations in neuronal development might underlie, at least in part, the learning deficit and decreased emotional reactivity observed in the offspring.
Long-term effects on cortical glutamate release induced by prenatal exposure to the cannabinoid receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone: an in vivo microdialysis study in the awake rat.
Tiziana Antonelli,Sergio Tanganelli,Maria Cristina Tomasini,Simone Finetti,Luigia Trabace,Luca Steardo,Valentina Sabino,Maria Rosaria Carratù,Vincenzo Cuomo,Luca Ferraro +9 more
TL;DR: Findings suggest that prenatal exposure to the CB1 receptor agonist WIN, at a concentration which is not associated with gross malformations and/or overt signs of toxicity, induces permanent alterations in cortical glutamatergic function.
46
Neurotensin Enhances Endogenous Extracellular Glutamate Levels in Primary Cultures of Rat Cortical Neurons: Involvement of Neurotensin Receptor in NMDA Induced Excitotoxicity
Tiziana Antonelli,Luca Ferraro,Kjell Fuxe,Simone Finetti,Jacqueline Fournier,Sergio Tanganelli,Monica De Mattei,Maria Cristina Tomasini +7 more
TL;DR: Under pathological conditions NT by enhancing glutamate outflow and by amplifying the NMDA-mediated glutamate signaling may be involved in increasing the degeneration of cortical neurons.
Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: counteraction by a NTR1-like receptor antagonist.
Zaida Díaz-Cabiale,Kjell Fuxe,José Ángel Narváez,Simone Finetti,Tiziana Antonelli,Sergio Tanganelli,Luca Ferraro +6 more
TL;DR: There exists in the striatum at the prejunctional level an intramembrane antagonistic NT receptor/DA D2 receptor-receptor interaction where NTR1 like receptor activation reduces the DA D2 autoreceptor function.
40
Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture
Tiziana Antonelli,Maria Cristina Tomasini,Simone Finetti,Luciana Giardino,Laura Calzà,Kjell Fuxe,P. Soubrie,Sergio Tanganelli,Luca Ferraro +8 more
TL;DR: In this article, the role of neurotensin in modulating glutamate excitotoxicity and the possible neuroprotective action of the neurotensor receptor antagonist SR48692 were investigated in primary cultures of mesencephalic neurons by measuring [(3)H]dopamine uptake and tyrosine hydroxylase immunocytochemistry 24 hr after glutamate treatment.
24