Simone Favini
University of Eastern Piedmont
6 Papers
23 Citations
Simone Favini is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Chronic lymphocytic leukemia & Gene mutation. The author has an hindex of 3, co-authored 5 publications.
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Papers
Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia.
Fary Diop,Riccardo Moia,Chiara Favini,Elisa Spaccarotella,Lorenzo De Paoli,Alessio Bruscaggin,Valeria Spina,Lodovico Terzi-di-Bergamo,Francesca Arruga,Chiara Tarantelli,Clara Deambrogi,Silvia Rasi,Ramesh Adhinaveni,Andrea Patriarca,Simone Favini,Sruthi Sagiraju,Clive Jabangwe,Ahad Ahmed Kodipad,Denise Peroni,Francesca Romana Mauro,Ilaria Del Giudice,Francesco Forconi,Agostino Cortelezzi,Francesco Zaja,Riccardo Bomben,Francesca Rossi,Carlo Visco,Annalisa Chiarenza,Gian Matteo Rigolin,Roberto Marasca,Marta Coscia,Omar Perbellini,Alessandra Tedeschi,Luca Laurenti,Marina Motta,David Donaldson,Phil Weir,Ken I. Mills,Patrick Thornton,Sarah Lawless,Francesco Bertoni,Giovanni Del Poeta,Antonio Cuneo,Antonia Follenzi,Valter Gattei,Renzo Boldorini,Mark Catherwood,Silvia Deaglio,Robin Foà,Gianluca Gaidano,Davide Rossi +50 more
TL;DR: It is shown that the non-canonical nuclear factor-κB pathway is active in BIRC3-mutated cell lines and in primary CLL samples, as documented by the stabilization of MAP3K14 and by the nuclear localization of p52, and may be used as a new molecular predictor to select high-risk patients for novel frontline therapeutic approaches.
The Usefulness of a Targeted Next Generation Sequencing Gene Panel in Providing Molecular Diagnosis to Patients With a Broad Spectrum of Neurodevelopmental Disorders
Simona Mellone,Chiara Puricelli,Denise Vurchio,Sara Ronzani,Simone Favini,Arianna Maruzzi,Cinzia Peruzzi,Amanda Papa,Alice Spano,Fabio Sirchia,Giorgia Mandrile,Alessandra Pelle,P. Rasmini,F Vercellino,Andrea Zonta,Ivana Rabbone,Umberto Dianzani,Maurizio Viri,Mara Giordano +18 more
TL;DR: The findings showed that this NGS panel represents a powerful and affordable clinical tool, significantly increasing the diagnostic yield in patients with different form of NDDs in a cost- and time-effective manner without the need of large investments in data storage and bioinformatic analysis.
Mechanisms of Adaptation to Ibrutinib in High Risk Chronic Lymphocytic Leukemia
Valeria Spina,Gabriela Forestieri,Antonella Zucchetto,Alessio Bruscaggin,Tamara Bittolo,Lodovico Terzi di Bergamo,Eva Szenes,Adalgisa Condoluci,Erika Tissino,Lorenzo De Paoli,Clara Deambrogi,Anna Maria Frustaci,Francesco Autore,Michele Merli,Lydia Scarfò,Claudia Cirillo Sanchez,Francesca Guidetti,Simone Favini,Fary Diop,Renzo Lucchini,Tanja Nicole Hartmann,Giovanni Del Poeta,Roberto Marasca,Francesco Zaja,Bernhard Gerber,Emanuele Zucca,Georg Stussi,Jakob Passweg,Paolo Ghia,Francesco Passamonti,Michael Gregor,Luca Laurenti,Marco Montillo,Alessandra Tedeschi,Franco Cavalli,Gianluca Gaidano,Valter Gattei,Davide Rossi +37 more
TL;DR: The results suggest that residual CLL cells persisting under ibrutinib therapy adapt their phenotype by upregulating adhesion molecules, chemokine receptors and BCR molecules, and by maintaining a competence of BCR signaling through the PI3K/AKT/ERK pathway.
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Liquid Biopsy As a Tool for Monitoring the Genotype of Diffuse Large B-Cell Lymphoma
Silvia Rasi,Sara Monti,Manuela Zanni,Carmela Ciardullo,Fary Diop,Lavinia Martuscelli,Elisa Spaccarotella,Valeria Spina,Alessio Bruscaggin,Simone Favini,Clara Deambrogi,Antonio Ramponi,Gianluca Gaidano,Davide Rossi +13 more
TL;DR: A targeted resequencing panel including the coding exons and splice sites of 59 genes that are recurrently mutated in mature B-cell tumors was specifically designed to allow the recovery of at least one mutation in >90% of DLBCL.
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BRAF and BIRC3 Mutations Stratify a Poor Prognostic Subgroup in FCR Treated Chronic Lymphocytic Leukemia
Fary Diop,Riccardo Moia,Chiara Favini,Elisa Spaccarotella,Lorenzo De Paoli,Alessio Bruscaggin,Valeria Spina,Michaela Cerri,Clara Deambrogi,Ahad Ahmed Kodipad,Simone Favini,Sruthi Sagiraju,Clive Jabangwe,Francesca Romana Mauro,Ilaria Del Giudice,Francesco Forconi,Agostino Cortelezzi,Francesco Zaja,Carlo Visco,Annalisa Chiarenza,Gian Matteo Rigolin,Roberto Marasca,Marta Coscia,Omar Perbellini,Alessandra Tedeschi,L Laurenti,Marina Motta,Giovanni Del Poeta,Antonio Cuneo,Valter Gattei,Robin Foà,Gianluca Gaidano,Davide Rossi +32 more
TL;DR: In this paper, the authors proposed a genetic-based stratification of FCR-treated CLL patients by integrating the mutational profile in a prognostic model together with the IGHV mutation status and FISH karyotype.
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