Simone Dallari
University of California, San Diego
5 Papers
Simone Dallari is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Arenavirus & TLR7. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Simone Dallari include University of Milan.
Chat about Author
Papers
Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection
Monica Macal,Yeara Jo,Simone Dallari,Aaron Y. Chang,Jihong Dai,Shobha Swaminathan,Ellen J. Wehrens,Patricia Fitzgerald-Bocarsly,Elina I. Zuniga +8 more
TL;DR: Findings unveil the mechanisms sustaining a self‐perpetuating pool of functionally exhausted pDCs and provide a framework for deciphering long‐term exhaustion of other short‐lived innate cells during chronic inflammation.
47
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection.
Maria Eugenia Loureiro,Andre Luiz Zorzetto-Fernandes,Sheli R. Radoshitzky,Xiaoli Chi,Simone Dallari,Nuha Marooki,Psylvia Leger,Sabrina Foscaldi,Vince Harjono,Sonia Sharma,Brian M. Zid,Nora López,Juan Carlos de la Torre,Sina Bavari,Elina I. Zuniga +14 more
TL;DR: Novel mechanisms used by arenaviruses to exploit the host machinery and subvert immunity are uncovered, singling out DDX3 as a potential host target for developing new therapies against highly pathogenic arenviruses.
Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses
Simone Dallari,Monica Macal,Maria Eugenia Loureiro,Yeara Jo,Lee Swanson,Charles Hesser,Partho Ghosh,Elina I. Zuniga +7 more
TL;DR: The role of Src family kinases (SFK) in mouse and human pDCs is shown and a tonic SFK-mediated signalling that precedes pathogen encounter is highlighted, raising the possibility that small molecules targeting SFKs could modulate pDC responses in human diseases.
36
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection
James A. Harker,Kurt A. Wong,Simone Dallari,Phuc Bao,Aleksandr Dolgoter,Yeara Jo,Ellen J. Wehrens,Monica Macal,Elina I. Zuniga +8 more
TL;DR: It is found that IL-27 receptor (IL-27R) signaling promoted control of LCMV Cl13 as early as days 1 and 5 after infection and that il27p28 transcripts were rapidly elevated in multiple subsets of dendritic cells (DCs) and myeloid cells, suggesting that a previously unrecognized positive-feedback loop mediated by IL- 27 in pDCs might be involved in this process.
DDX3 is exploited by Arenaviruses to suppress type I interferons and favor their replication
Maria Eugenia Loureiro,Andre Luiz Zorzetto-Fernandes,Sheli R. Radoshitzky,Xiaoli Chi,Simone Dallari,Nuha Marooki,Psylvia Leger,Sabrina Foscaldi,Sonia Sharma,Nora López,de la Torre Jc,Sina Bavari,Elina I. Zuniga +12 more
TL;DR: This study established DDX3 as a critical host interacting partner of the arenavirus nucleoprotein and demonstrated two previously unrecognizedDDX3-dependent strategies by which these deadly viruses exploit the host cellular machinery and suppress immunity.