Simon Young
AstraZeneca
30 Papers
108 Citations
Simon Young is an academic researcher from AstraZeneca. The author has contributed to research in topics: COPD & Asthma. The author has an hindex of 10, co-authored 30 publications. Previous affiliations of Simon Young include Loughborough University.
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Papers
Polyethylene glycol-drug ester conjugates for prolonged retention of small inhaled drugs in the lung
F. J. C Bayard,Wim Thielemans,David I. Pritchard,Stuart W. Paine,Simon Young,P Backman,P Ewing,Cynthia Bosquillon +7 more
TL;DR: This study is the first to demonstrate hydrolysable PEG drug ester conjugates are a promising approach for optimising the pharmacokinetic profile of small drugs delivered by inhalation.
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Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD
Alexandra R. Morgan,Geoff J M Parker,Caleb Roberts,Giovanni A Buonaccorsi,Niall C. Maguire,Penny L. Hubbard Cristinacce,Dave Singh,Jørgen Vestbo,Leif Bjermer,Jonas Jögi,Ziad Taib,Janeli Sarv,Piet L.B. Bruijnzeel,Lars E. Olsson,Eva Bondesson,Ulf Nihlén,Ulf Nihlén,Deirdre M. McGrath,Simon Young,John C. Waterton,John C. Waterton,Lars H. Nordenmark +21 more
TL;DR: In COPD, OE-MRI parameters showed response to both single-dose bronchodilatory effects of a β2-agonist, formoterol, and 8-week treatment with an inhaled corticosteroid, budesonide, and the measurements are feasible in a small-scale multi-center trial setting.
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Eosinophil-derived neurotoxin: A biologically and analytically attractive asthma biomarker.
Bert Rutten,Simon Young,Magdalena Rhedin,Marita Olsson,Nisha Kurian,Farhat Syed,Augusta Beech,Mark Fidock,Paul Newbold,Dave Singh,Adam Platt,Glen Hughes +11 more
TL;DR: In this article, the eosinophil-derived neurotoxin (EDN) was used as a biomarker in asthma patients, and the reference range for men and women was defined as 1.98 to 26.10 ng/mL, with no significant gender differences.
COPD Patients Have Short Lung Magnetic Resonance T1 Relaxation Time.
Daniel F. Alamidi,Alexandra R. Morgan,Penny L. Hubbard Cristinacce,Lars H. Nordenmark,Paul D. Hockings,Kerstin M. Lagerstrand,Simon Young,Josephine H. Naish,John C. Waterton,Niall C. Maguire,Lars E. Olsson,Geoffrey J. M. Parker +11 more
TL;DR: L lung MRI T1 mapping shows potential as a repeatable, radiation free, non-invasive imaging technique in the evaluation of COPD.
A texture analysis approach to quantify ventilation changes in hyperpolarised ³He MRI of the rat lung in an asthma model.
TL;DR: Texture analysis can be used to quantify changes in lung ventilation as measured with HP 3He MRI after therapeutic intervention with budesonide, and was able to show significant differences between the control and untreated vehicle groups as well as between the vehicle and treatment groups.
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