Chronic inflammation is triggered by numerous diseases such as osteoarthritis, Crohn's disease and cancer. The control of the pro-inflammatory process can prevent, mitigate and/or inhibit the evolution of these diseases. Therefore, anti-inflammatory drugs have been studied as possible compounds to act in these diseases. This paper proposes a computational analysis of eugenol in relation to aspirin and diclofenac and analyzing the ADMET profile and interactions with COX-2 and 5-LOX enzymes, important enzymes in the signaling pathway of pro-inflammatory processes. Through the analysis of ADMET in silico, it was found that the pharmacokinetic results of eugenol are similar to NSAIDs, such as diclofenac and aspirin. Bioinformatics analysis using coupling tests showed that eugenol can bind to COX-2 and 5-LOX. These results corroborate with different findings in the literature that demonstrate anti-inflammatory activity with less gastric irritation, bleeding and ulcerogenic side effects of eugenol. The results of bioinformatics reinforce studies that try to propose eugenol as an anti-inflammatory compound that can act in the COX-2/5-LOX pathways, replacing some NSAIDs in different diseases.

/pdf/computational-analysis-of-eugenol-inhibitory-activity-in-3zg02rk4ik.pdf

Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways.

Developmental alterations, teratogenic effects, and oxidative disruption induced by ibuprofen, aluminum, and their binary mixture on Danio rerio.

NAD+ in sulfur mustard toxicity.

This paper evaluated the inhibition performance of Ibuprofen drug (ID) on pure copper in 0.5 ​M ​H2SO4. The corrosion resistance enhancement ability of Ibuprofen drug was examined through potentiodynamic polarization experiment. The results of the experiment show that the pure copper exhibit the corrosion rate (Cr), current density (jcorr) and polarization resistance (Pr) of 11.901 ​mm/year, 1024.20 ​μA/cm2 and 4.9561 ​Ω, respectively. However, the maximum inhibited copper sample exhibit the Cr, jcorr and Pr of 1.0953 ​mm/year, 94.30 ​μA/cm2 and 92.348 ​Ω, respectively. More so, the inhibition efficiency (I.E) ranging from 78.43 to 90.79% was recorded. The inhibition performance of Ibuprofen drug is due to the ability of its molecules to protect the anodic and cathodic sites of the copper samples by the inhibitive drug. The mixed inhibition characteristic of the Ibuprofen drug molecules was established by the Tafel curve. The Langmuir adsorption isotherm revealed R2 value of 0.9850, which indicates the efficacy of Ibuprofen drug as an inhibitor. The Optical microscope (OPM) micrographs further confirmed the adsorption of Ibuprofen drug molecules on the copper surface.

Evaluation of inhibitive performance of Ibuprofen drug on copper in 0.5 M H2SO4

Pharmaceutical and clinical studies of celecoxib topical hydrogel for management of chemotherapy-induced hand-foot syndrome

Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes

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Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes