Simon Strietholt
University of Münster
9 Papers
87 Citations
Simon Strietholt is an academic researcher from University of Münster. The author has contributed to research in topics: Matrix metalloproteinase & Arthritis. The author has an hindex of 7, co-authored 9 publications.
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Papers
Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression☆
Hanna Maciejewska-Rodrigues,Emmanuel Karouzakis,Simon Strietholt,Hossein Hemmatazad,Michel Neidhart,Caroline Ospelt,Beat A. Michel,Thomas Pap,Astrid Jüngel +8 more
TL;DR: This is the first study linking the SUMOylation pathway and the production of MMP-1 to an epigenetic control mechanism mediated through histone acetylation which has a functional consequence for the invasiveness of RASF.
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Epigenetic modifications in rheumatoid arthritis
TL;DR: Insight is provided into the role of epigenetic alterations in the pathogenesis of rheumatoid arthritis and how a better understanding of such mechanisms may lead to novel therapeutic strategies.
PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis.
Silvia Hayer,Noreen Pundt,Marvin A. Peters,C Wunrau,Inga Kühnel,Katja Neugebauer,Simon Strietholt,Jochen Zwerina,Adelheid Korb,Josef M. Penninger,Leo A. B. Joosten,Thomas Rückle,Georg Schett,Thomas Pap +13 more
TL;DR: It is shown that in human tumor necrosis factor transgenic mice, the loss of PI3Kγ leads to a milder inflammatory arthritis, and in human synovial fibroblasts from patients with RA who exhibit a disease‐specific up‐regulation of PI2Kγ, the decreased invasiveness of fibro Blasts is mediated by reduced phosphorylation of Akt and extracellular signalregulated kinase.
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The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.
Marvin A. Peters,Doreen Wendholt,Simon Strietholt,Svetlana Frank,Noreen Pundt,Adelheid Korb-Pap,Leo A. B. Joosten,Wim B. van den Berg,George Kollias,Beate Eckes,Thomas Pap +10 more
TL;DR: It is suggested that α2β1 integrin contributes significantly to inflammatory cartilage destruction by promoting fibroblast proliferation and attachment and MMP expression.
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Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB
Svetlana Frank,Marvin A. Peters,Corinna Wehmeyer,Simon Strietholt,Christina Koers-Wunrau,Jessica Bertrand,Marianne Heitzmann,Anja Hillmann,J. Sherwood,Christine Seyfert,Thomas Pap +10 more
TL;DR: It is shown that despite their high homology, SUMO-2/3 are differentially regulated by T NF-α and selectively control TNF-α mediated MMP expression via the NF-κB pathway.