Simon Storevik
4 Papers
Simon Storevik is an academic researcher. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 2, co-authored 3 publications.
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Papers
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
Dionysios C. Watson,Defne Bayık,Simon Storevik,Shannon Sherwin Moreino,Samuel A. Sprowls,Jianhua Han,Adam Lauko,Palavalasa Sravya,Gro V. Røsland,Katie M. Troike,Karl Johan Tronstad,Sabrina Wang,Katharina Sarnow,K. Kay,Taral R. Lunavat,Daniel J. Silver,Sahil Dayal,Justin V. Joseph,Erin E. Mulkearns-Hubert,Lars A. Rømo Ystaas,Gauravi M. Deshpande,Joris Guyon,Yadi Zhou,Capucine R. Magaut,Juliana Seder,Laura Neises,Sara E. Williford,Johannes Meiser,Andrew J. Scott,Peter Sajjakulnukit,Jason A. Mears,Rolf Bjerkvig,Abhishek A. Chakraborty,Thomas Daubon,Feixiong Cheng,Costas A. Lyssiotis,Daniel R. Wahl,Anita B. Hjelmeland,Jubayer A Hossain,Hrvoje Miletic,Justin D. Lathia +40 more
TL;DR: In this paper , the authors show that mitochondria transfer is a prevalent phenomenon in glioblastoma (GBM), the most frequent and malignant primary brain tumor, and identify horizontal mitochondria transfers from astrocytes as a mechanism that enhances tumorigenesis in GBM.
Abstract 331: Mitochondrial transfer from astrocytes drives glioblastoma tumorigenicity
Dionysios C. Watson,Defne Bayık,Simon Storevik,Shannon Sherwin Moreino,Gauravi M. Deshpande,Palavalasa Sravya,Costas A. Lyssiotis,Daniel R. Wahl,Hrvoje Miletic,Justin D. Lathia +9 more
TL;DR: Watson et al. as mentioned in this paper showed that mitochondrial transfer from non-neoplastic cells in the surrounding microenvironment to glioblastoma (GBM) cells supports tumor metabolism and growth.
Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
Claire M Larrieu,Simon Storevik,Joris Guyon,Antonio C Pagano Zottola,Cyrielle Bouchez,Marie-Alix Derieppe,Tuan Zea Tan,Hrvoje Miletic,James B. Lorens,Karl Johan Tronstad,Thomas Daubon,Gro V. Røsland +11 more
TL;DR: Targeting cancer cell metabolism, specifically the pyruvate dehydrogenase (PDH) regulators PDH kinases (PDHK), to disturb GB progression and render cells vulnerable to additional cancer treatment confirmed a reduction in tumor size and better survival of mice implanted with PDHK1 and PDHK2 knockout cells.
TGF-β promotes microtube formation in glioblastoma through thrombospondin 1
Justin V. Joseph,Capucine R. Magaut,Simon Storevik,Luiz H Geraldo,Thomas Mathivet,M. A. Latif,Justine Rudewicz,Joris Guyon,Matteo Gambaretti,Frida Haukås,Amalie Trones,Lars A. Rømo Ystaas,Jubayer A Hossain,Sandra Ninzima,Sylvain Cuvellier,Wenjing Zhou,Tushar Tomar,Barbara Klink,Lalit Rane,Bronwyn K. Irving,Joanne Marrison,Peter O’Toole,Heiko Wurdak,Jian Wang,Zhang Di,Even Birkeland,Frode S. Berven,Frank Winkler,Frank A.E. Kruyt,A. Bikfalvi,R. Bjerkvig,Thomas Daubon,H. Miletic +32 more
TL;DR: TGF-β and its downstream mediator TSP1 are important mediators of the MT network in GBM and blocking this pathway could potentially help to break the complex MT-driven invasion/resistance network.