Simon Söderholm

TL;DR: Using a combination of time-resolved CUT&RUN against β-catenin, ATAC-seq, and perturbation assays in different cell types, Wang et al. as mentioned in this paper showed that Wnt/β-Catenin physical targets are tissue-specific, β-CatENin "moves" on different loci over time, and its association to DNA accompanies changing chromatin accessibility landscapes that determine cell behavior.

TL;DR: It is found that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain the action of β-catenin in a largely PYGO-independent manner, which implicates TBX3 as a new, context-dependent component of the Wnt/β- catenin-dependent enhanceosome.

TL;DR: This article showed that deletion of the four genes encoding the TCF/LEF transcription factors confers mESCs with the ability to self-renew in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF).

TL;DR: TBX3 emerges as a key modulator of the oncogenic activity of Wnt/β-catenin in colorectal cancer, and its mechanism of action exposes a novel druggable protein-interaction surface.