Simon P. Mooijaart

TL;DR: Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

TL;DR: This paper aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available.

TL;DR: Levothyroxine provided no apparent benefits in older persons with subclinical hypothyroidism and there was no significant excess of serious adverse events prespecified as being of special interest.

TL;DR: A well-standardized metabolomics platform is used to identify metabolic predictors of long-term mortality in the circulation of 44,168 individuals and identifies key metabolites independently associated with all-cause mortality risk.