Simon Lowes
Newcastle University
17 Papers
121 Citations
Simon Lowes is an academic researcher from Newcastle University. The author has contributed to research in topics: Breast cancer & Breast imaging. The author has an hindex of 7, co-authored 17 publications. Previous affiliations of Simon Lowes include Royal Victoria Infirmary & University of Newcastle.
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Papers
Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells
Simon Lowes,Nicholas L. Simmons +1 more
TL;DR: Human intestinal epithelial Caco‐2 cells, T84 cells, and MDCKII cells transfected with human MDR1, were used to investigate the mechanistic basis of transintestinal fluoroquinolone secretion, finding that the transepithelial secretion of grepafloxacin is mediated by both MRP2 and M DR1, whereas ciprofloxacIn is a substrate for neither.
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High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis.
TL;DR: This comprehensive, inclusive assessment of all published literature provides an accurate estimate of malignancy risk in subgroups of B3 lesions, to guide tailored management strategies.
Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers.
TL;DR: Caco-2 epithelial layers were used as a model to re-evaluate the mechanism(s) by which intestinal digoxin absorption is limited by its active secretion back into the lumen, suggesting that an additional non-MDR1 component may contribute to this transport.
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Use of Hologic LOCalizer radiofrequency identification (RFID) tags to localise impalpable breast lesions and axillary nodes: experience of the first 150 cases in a UK breast unit.
TL;DR: The RFID tag system demonstrates many advantages over guidewires, and is effective at targeting axillary lymph nodes and multiple sites within the same breast, including the first reported use of RFID tags in the axilla.
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Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
TL;DR: A review draws on the current knowledge of the roles of SLC transporters in human cancers in order to highlight the potential significance of these solute carriers in breast cancer pathogenesis and treatment.