Simon Litvak
Centre national de la recherche scientifique
123 Papers
2.1K Citations
Simon Litvak is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Reverse transcriptase & DNA polymerase. The author has an hindex of 34, co-authored 123 publications.
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Papers
Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA.
TL;DR: The present results show that finger protein p12 of Rous sarcoma virus (RSV) and p10 of murine leukaemia virus (MuLV) positions replication primer tRNA on the replication initiation site (PBS) at the 5′ end of the RNA genome.
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HIV-1 integrase crosslinked oligomers are active in vitro.
Aurelie Faure,Christina Calmels,Cécile Desjobert,Michel Castroviejo,Anne Caumont-Sarcos,Laura Tarrago-Litvak,Simon Litvak,Vincent Parissi +7 more
TL;DR: The data suggest that the tetrameric IN bound to the viral DNA ends is the minimal complex involved in the concerted integration of both LTRs and should be the oligomeric form targeted by future inhibitors.
Evaluation of selected South African medicinal plants for inhibitory properties against human immunodeficiency virus type 1 reverse transcriptase and integrase
Pascal O. Bessong,Chikwela Lawrence Obi,Marie Line Andreola,Luis B. Rojas,Luis B. Rojas,Laurent Pouységu,E. O. Igumbor,J.J. Marion Meyer,Stéphane Quideau,Simon Litvak +9 more
TL;DR: The strongest inhibition against the RNA-dependent-DNA polymerase (RDDP) activity of RT was observed with the methanol extract of the stem-bark of Peltophorum africanum Sond.
166
Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells. Biochemical properties and interactions with bovine tRNALys.
Marie-Line Sallafranque-Andreola,Dominique Robert,Philip J. Barr,Michel Fournier,Simon Litvak,Leila Sarih-Cottin,Laura Tarrago-Litvak +6 more
TL;DR: A complex between the human retroviral enzyme and the bovine t RNALys was shown, using a direct approach, by glycerol gradient centrifugation, as well as by the protective and specific effect of the tRNALys against enzyme inactivation by thermal denaturation and trypsin digestion.
82
HCV RNA-dependent RNA polymerase replicates in vitro the 3′ terminal region of the minus-strand viral RNA more efficiently than the 3′ terminal region of the plus RNA
Sandrine Reigadas,Michel Ventura,Leila Sarih-Cottin,Michel Castroviejo,Simon Litvak,Thérèse Astier-Gin +5 more
TL;DR: Results indicate that the 3' end of the minus-strand RNA of HCV possesses some sequences and structure elements well recognized by the purified NS5B.
79