Simon Lattmann
Friedrich Miescher Institute for Biomedical Research
9 Papers
Simon Lattmann is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: DHX36 & RNA. The author has an hindex of 5, co-authored 5 publications.
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Papers
DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation.
Ji-Seung Yoo,Kiyohiro Takahasi,Chen Seng Ng,Ryota Ouda,Koji Onomoto,Mitsutoshi Yoneyama,Janice Ching Lai,Simon Lattmann,Yoshikuni Nagamine,Tadashi Matsui,Kuniyoshi Iwabuchi,Hiroki Kato,Takashi Fujita +12 more
TL;DR: A novel function of DHX36 is identified as a critical regulator of PKR-dependent avSG to facilitate viral RNA recognition by RIG-I-like receptor (RLR).
Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain.
Kateřina Chalupníková,Simon Lattmann,Nives Selak,Fumiko Iwamoto,Yukio Fujiki,Yoshikuni Nagamine +5 more
TL;DR: The results show that RHAU is the fourth RNA helicase detected in SGs, after rck/p54, DDX3, and eIF4A, and that its association with SGs is dynamic and mediated by an R HAU-specific RNA-binding domain.
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Crystal structures of an HIV-1 integrase aptamer: Formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex.
TL;DR: In this article , Wu et al. have determined several high-resolution crystal structures of 93del and its variants and revealed important detailed structural information, particularly the formation of a water-mediated A•G•G •G • G•G pentad, which can be useful for designing and manipulating G-quadruplex scaffolds with desired properties.
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Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU
TL;DR: Results reveal a novel motif in RHAU protein that plays an important role in recognizing and resolving G4-RNA structures, properties unique to R HAU among many known RNA helicases.
A high-throughput cell-based screening method for Zika virus protease inhibitors discovery.
Paulina Duhita Anindita,Yuka Otsuka,Simon Lattmann,Khac Huy Ngo,Chong Wai Liew,CongBao Kang,Reuben S. Harris,Louis Scampavia,Timothy P. Spicer,Dahai Luo +9 more
- 01 May 2024
TL;DR: Researchers developed a high-throughput cell-based assay to screen for Zika virus protease inhibitors, leveraging the virus's protease activity to cleave a luciferase-fused substrate, demonstrating assay feasibility for compound library screening to identify potential inhibitors.