Simon Lang
5 Papers
28 Citations
Simon Lang is an academic researcher. The author has contributed to research in topics: In vivo & Janus kinase. The author has an hindex of 3, co-authored 5 publications.
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Papers
Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes.
Simon Lang,Tanja Popp,Christian Silvester Kriegs,Annette M. Schmidt,Frank Balszuweit,Georg Menacher,Kai Kehe,Horst Thiermann,Thomas Gudermann,Dirk Steinritz +9 more
TL;DR: Overall, BER has protective effects against SM toxicity in vitro, and whether this holds true should be evaluated in future in vivo studies.
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Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes
Simon Wagner,Simon Lang,Tanja Popp,Annette M. Schmidt,Horst Thiermann,Dirk Steinritz,Kai Kehe +6 more
TL;DR: The COX-2 specific celecoxib was identified as the most potent drug to reduce IL-6, IL-8 and TNF-α formation after SM exposures in vitro, however, cell viability was not improved significantly by any of the investigated drugs in the authors' experiments.
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Bardoxolone-Methyl (CDDO-Me) Impairs Tumor Growth and Induces Radiosensitization of Oral Squamous Cell Carcinoma Cells.
Cornelius Hermann,Simon Lang,Tanja Popp,Susanne Hafner,Dirk Steinritz,Alexis Rump,Matthias Port,Stefan Eder +7 more
TL;DR: In this article, the authors used normal human epithelial keratinocytes (NHEK) and oral squamous cell carcinoma (OSCC) cells (Cal-27) as models to investigate radio-modulating and anti-tumor effects of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid methyl ester (CDDO-Me).
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.
Dirk Steinritz,Simon Lang,Tanja Popp,Markus Siegert,Simone Rothmiller,Andreas Kranawetvogl,Annette M. Schmidt,Harald John,Thomas Gudermann,Horst Thiermann,Kai Kehe +10 more
TL;DR: The skin sensitizing potential of SM and three related alkylating agents (AAs) was assessed following the OECD test guidelines and a tentative AOP for SM-induced skin sensitization is suggested.
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Necrosulfonamide – Unexpected effect in the course of a sulfur mustard intoxication
Georg Menacher,Frank Balszuweit,Simon Lang,Horst Thiermann,Kai Kehe,Thomas Gudermann,Annette Schmidt,Dirk Steinritz,Tanja Popp +8 more
TL;DR: The influence of necrosulfonamide (NSA) on the course of a SM intoxication in vitro is reported to highlight NSA as a candidate compound to address cell death and inflammation in SM exposure.
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