Simon J. White
University of Connecticut
30 Papers
57 Citations
Simon J. White is an academic researcher from University of Connecticut. The author has contributed to research in topics: Capsid & RNA. The author has an hindex of 8, co-authored 23 publications. Previous affiliations of Simon J. White include University of Leeds & University of York.
Chat about Author
Papers
Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2
Ottar Rolfsson,Stefani Middleton,Iain W. Manfield,Simon J. White,Baochang Fan,Robert C. Vaughan,Neil A. Ranson,Eric C. Dykeman,Reidun Twarock,James Ford,C. Cheng Kao,Peter G. Stockley +11 more
TL;DR: Using cross-linking coupled to matrix-assisted laser desorption/ionization mass spectrometry and CLIP-Seq sequencing, the peptide and oligonucleotide sequences at the interfaces between the capsid proteins and the genomic RNA of bacteriophage MS2 are determined.
105
Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays.
Nicola Derbyshire,Simon J. White,David H.J. Bunka,Lei Song,Sara Stead,Jonathan A. Tarbin,Matthew Sharman,Dejian Zhou,Peter G. Stockley +8 more
TL;DR: It is shown that this lack of aminoglycoside specificity is a common property of aptamers previously selected against single compounds and described as “specific”, which would be ideal for sensors detecting the entire class of am inoglycosides.
95
HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly.
Nikesh Patel,Simon J. White,Rebecca F. Thompson,Richard J. Bingham,Eva U. Weiß,D.P. Maskell,Adam Zlotnick,Eric C. Dykeman,Roman Tuma,Reidun Twarock,Neil A. Ranson,Peter G. Stockley +11 more
TL;DR: Using RNA SELEX and bioinformatics, multiple regions in the pre-genomic RNA with high affinity for core protein dimers are identified that trigger sequence-specific assembly of virus-like particles (VLPs) at much higher fidelity and yield than in the absence of RNA.
Genomic RNA folding mediates assembly of human parechovirus
Shabih Shakeel,Eric C. Dykeman,Simon J. White,Ari Ora,Ari Ora,Joseph J.B. Cockburn,Sarah J. Butcher,Peter G. Stockley,Reidun Twarock +8 more
TL;DR: A correction to this article has been published and is linked from the HTML version of this article.
Modeling Coronavirus Spike Protein Dynamics: Implications for Immunogenicity and Immune Escape.
TL;DR: In this paper, the authors developed computational models for a large subset of S proteins associated with SARS-CoV-2, implemented through coarse-grained elastic network models and normal mode analysis.
20