Simon J. Waddell
Brighton and Sussex Medical School
72 Papers
212 Citations
Simon J. Waddell is an academic researcher from Brighton and Sussex Medical School. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 24, co-authored 61 publications. Previous affiliations of Simon J. Waddell include Stanford University & St George's Hospital.
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Papers
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov,Giulia Manina,Katarína Mikušová,Ute Möllmann,O. B. Ryabova,Brigitte Saint-Joanis,Neeraj Dhar,Maria Rosalia Pasca,Silvia Buroni,Anna Paola Lucarelli,Anna Milano,Edda De Rossi,Martina Belanova,Adela Bobovská,Petronela Dianišková,Jana Korduláková,Claudia Sala,Elizabeth Fullam,Patricia Schneider,John D. McKinney,Priscille Brodin,Thierry Christophe,Simon J. Waddell,Philip D. Butcher,Jakob Albrethsen,Ida Rosenkrands,Roland Brosch,Vrinda Nandi,Sowmya Bharath,Sheshagiri Gaonkar,Radha Shandil,V. Balasubramanian,Tanjore S. Balganesh,Sandeep Tyagi,Jacques H. Grosset,Giovanna Riccardi,Stewart T. Cole +36 more
TL;DR: The synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB are described.
Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum
Natalie J. Garton,Simon J. Waddell,Anna L Sherratt,Su-Min Lee,Rebecca J. Smith,Claire E. Senner,Jason Hinds,Kumar Rajakumar,Richard A. Adegbola,Gurdyal S. Besra,Philip D. Butcher,Michael R. Barer +11 more
TL;DR: Transcript analyses refute the hypothesis that these cells predominate in sputum and reinforce the results of the lipid body analyses by revealing transcriptional signatures that can be clearly attributed to slowly replicating or nonreplicating mycobacteria.
Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ
Beate Kampmann,Cheryl Hemingway,Alick C Stephens,Robert N. Davidson,Anna Goodsall,Suzanne T. Anderson,Mark P. Nicol,Elisabeth H. Schölvinck,David A. Relman,Simon J. Waddell,Paul R. Langford,Brian J. Sheehan,Lynn Semple,Katalin A. Wilkinson,Robert J. Wilkinson,Stanley R. Ress,Martin L. Hibberd,Michael Levin +17 more
TL;DR: It is postulated that acquired defects in macrophage activation by IFN-gamma may cause a similar immunological phenotype and thus explain the occurrence of disseminated intracellular infections in some patients without identifiable immune deficiency.
Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages
Ludovic Tailleux,Simon J. Waddell,Mattia Pelizzola,Alessandra Mortellaro,Michael Withers,Antoine Tanne,Paola Ricciardi Castagnoli,Brigitte Gicquel,Neil G. Stoker,Philip D. Butcher,Maria Foti,Olivier Neyrolles +11 more
TL;DR: This study has been able to investigate gene expression changes in both Mycobacterium tuberculosis and its human host cells, macrophages and dendritic cells, and identify eukaryotic and microbial transcriptional signatures that are specific to the cell type involved in the infection process.
205
Dissecting interferon-induced transcriptional programs in human peripheral blood cells.
Simon J. Waddell,Stephen J. Popper,Kathleen H. Rubins,Michael J. Griffiths,Patrick O. Brown,Patrick O. Brown,Michael Levin,David A. Relman,David A. Relman +8 more
TL;DR: Cell type-specific transcriptional programs were identified, highlighting the pronounced response of monocytes to IFNγ, and emergent properties associated with IFN-mediated activation of mixed cell populations, and contributes an interpretive framework for the definition of host immune responses in a variety of disease settings.
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