Simon Hoffenberg
International AIDS Vaccine Initiative
30 Papers
203 Citations
Simon Hoffenberg is an academic researcher from International AIDS Vaccine Initiative. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 12, co-authored 30 publications. Previous affiliations of Simon Hoffenberg include Baylor College of Medicine & Regeneron.
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Papers
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
Leopold Kong,Jeong Hyun Lee,Katie J. Doores,Katie J. Doores,Katie J. Doores,Charles D. Murin,Jean-Philippe Julien,Jean-Philippe Julien,Ryan McBride,Yan Liu,Andre J. Marozsan,Albert Cupo,Per Johan Klasse,Simon Hoffenberg,Michael J. Caulfield,C. Richter King,Yuanzi Hua,Yuanzi Hua,Khoa Le,Khoa Le,Reza Khayat,Marc C. Deller,Thomas Clayton,Henry Tien,Ten Feizi,Rogier W. Sanders,Rogier W. Sanders,James C. Paulson,John P. Moore,Robyn L. Stanfield,Robyn L. Stanfield,Dennis R. Burton,Andrew B. Ward,Andrew B. Ward,Ian A. Wilson +34 more
TL;DR: Combined structural studies of PGT 135, PGT 128 and 2G12 show that this Asn332-dependent antigenic region is highly accessible and much more extensive than initially appreciated, which allows for multiple binding modes and varied angles of approach; thereby it represents a supersite of vulnerability for antibody neutralization.
Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes.
Simon Hoffenberg,Rebecca L.R. Powell,Alexei Carpov,Denise Wagner,Aaron J. Wilson,Sergei L. Kosakovsky Pond,Ross W. B. Lindsay,Heather Arendt,Joanne DeStefano,Sanjay Phogat,Pascal Poignard,Steven P. Fling,Melissa Simek,Celia C. LaBranche,David C. Montefiori,Terri Wrin,Pham Phung,Dennis R. Burton,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,C. Richter King,Christopher L. Parks,Michael J. Caulfield +23 more
TL;DR: The BG505 Env protein warrants further investigation as an HIV vaccine candidate, as a stand-alone protein, or as a component of a vaccine vector.
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Evidence for a Symmetrical Requirement for Rab5-GTP in in Vitro Endosome-Endosome Fusion
M. Alejandro Barbieri,Simon Hoffenberg,Richard Roberts,Amitabha Mukhopadhyay,Andrea Pomrehn,Burton F. Dickey,Philip D. Stahl +6 more
TL;DR: It is concluded that Rab5-GTP is required on both sets of endosomes for docking and fusion of early endosome fusion in vitro and in living cells.
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Traffic control: Rab GTPases and the regulation of interorganellar transport.
TL;DR: The Ras-related Rab GTPases play multiple roles in regulating this traffic of membrane proteins, membrane lipids, and luminal contents exchanged among the intracellular compartments of eukaryotic cells by vesicular transport.
66
Preclinical assessment of anti-CD40 Mab 5D12 in cynomolgus monkeys
Louis Boon,Jon D. Laman,Antonio Ortiz-Buijsse,Marcel T. den Hartog,Simon Hoffenberg,Patrick Liu,Fred Shiau,Mark de Boer +7 more
TL;DR: The identical staining patterns in human and cynomolgus tissues justified the use of cynomlgus monkeys as a relevant model for humans and a GLP-compliant safety and tolerability evaluation for ch5D12 was performed using the GMP produced material.
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