Simon Brunel
La Jolla Institute for Allergy and Immunology
5 Papers
Simon Brunel is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Medicine & Apolipoprotein B. The author has an hindex of 1, co-authored 1 publications.
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Papers
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells
Dennis Wolf,Dennis Wolf,Teresa Gerhardt,Teresa Gerhardt,Holger Winkels,Nathaly Anto Michel,Nathaly Anto Michel,Akula Bala Pramod,Akula Bala Pramod,Yanal Ghosheh,Simon Brunel,Konrad Buscher,Jacqueline Miller,Sara McArdle,Livia Baas,Kouji Kobiyama,Melanie Vassallo,Erik Ehinger,Thamotharampillai Dileepan,Amal J. Ali,Maximilian Schell,Zbigniew Mikulski,Daniel Sidler,Takayuki Kimura,Xia Sheng,Hauke Horstmann,Sophie Hansen,Lucia Sol Mitre,Peter Stachon,Ingo Hilgendorf,Dalia E. Gaddis,Catherine C. Hedrick,Chris A. Benedict,Bjoern Peters,Andreas Zirlik,Alessandro Sette,Klaus Ley +36 more
TL;DR: An unexpected mixed phenotype of apoB-reactive autoimmune T cells in atherosclerosis is demonstrated and an initially protective autoimmune response against apolipoprotein B100 with a progressive derangement in clinical disease is suggested.
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Divergent metabolic programmes control two populations of MAIT cells that protect the lung
Thomas Riffelmacher,Chantal Wientjens,Shilpi Chandra,Viankail Cedillo-Castelán,Ting-Fang Chou,Sara McArdle,Christopher H. Dillingham,Jordan J. Devereaux,Aaron Nilsen,Simon Brunel,David M. Lewinsohn,Jeff Hasty,Grégory Seumois,Chris A. Benedict,Pandurangan Vijayanand,Mitchell Kronenberg +15 more
TL;DR: In this article , following pulmonary immunization with a Salmonella vaccine strain, mouse mucosal-associated invariant T (MAIT) cells expanded as separate CD127-Klrg1+ and CD127 + Klrg 1+ antigen-adapted populations that differed in terms of their transcriptome, function and localization in lung tissue.
Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy
Rémi Marrocco,R. Medari,P. Salu,Meza E Lucero,Simon Brunel,A. Martsinkovskiy,S. Sun,K. Gulay,M. Jaljuli,E. Mose,A. Lowy,CA Benedict,Tatiana Hurtado de Mendoza +12 more
The GATE glycoprotein complex enhances human cytomegalovirus entry in endothelial cells.
Michael J Norris,Lauren A. Henderson,Mohammed N. A. Siddiquey,Jieyun Yin,Kwangsun Yoo,Simon Brunel,Michael Mor,Erica Ollmann Saphire,Chris A Benedict,Jeremy P. Kamil +9 more
Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells
Felix Sebastian Nettersheim,Yanal Ghosheh,Holger Winkels,Kouji Kobiyama,Christopher P. Durant,Sujit Silas Armstrong,Simon Brunel,Payel Roy,Thamotharampillai Dileepan,Marc K. Jenkins,Dirk M. Zajonc,Klaus Ley +11 more
TL;DR: In this article , the authors performed single-cell RNA sequencing of tetramer-sorted ApoB-reactive P6+ T cells and found that the expanded T cells had a strong Treg signature and highly expressed genes mediating suppressive functions.