Simon Baumberg
University of Leeds
66 Papers
872 Citations
Simon Baumberg is an academic researcher from University of Leeds. The author has contributed to research in topics: Bacillus subtilis & Escherichia coli. The author has an hindex of 26, co-authored 66 publications.
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Papers
Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis
TL;DR: The data are consistent with the binding of a single hexamer of AhrC to argCO1 via four of its subunits, possibly allowing the remaining two subunits to bind at argCO2 in vivo forming a repression loop similar to those observed for the E coli Lac repressor.
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Identification of a chromosomally encoded abc-transport system with which the staphylococcal erythromycin exporter msra may interact
TL;DR: Results indicate that the chromosomes of S. hominis and S. aureus contain sequences encoding a potential TM protein with which MsrA might interact.
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Operator interactions by the Bacillus subtilis arginine repressor/activator, AhrC: novel positioning and DNA‐mediated assembly of a transcriptional activator at catabolic sites
TL;DR: The characterization by gel retardation and DNase I footprinting of both OrocA and OrocD and a novel model for the assembly of a higher affinity form of AhrC at operator sites that is consistent with both the apparent co‐operativity of binding and the anti‐competitive effects are proposed.
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Control regions within the argECBH gene cluster of Escherichia coli K12.
TL;DR: The hypothesis that argE and argCBH form two operons transcribed in opposite directions from an internal promoter-operator complex is discussed, and it is suggested that a secondary promoter exists at or near the argB-H boundary.
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Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220.
TL;DR: To define the minimal functional unit required for MSR, the control region within the leader sequence of msrA was deleted and resulted in constitutive resistance to Er and type B streptogramins (Sg), proving that SgR does not require the presence of Er.
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