Simon Badoud
University of Fribourg
9 Papers
5 Citations
Simon Badoud is an academic researcher from University of Fribourg. The author has contributed to research in topics: Premotor cortex & Primary motor cortex. The author has an hindex of 5, co-authored 9 publications.
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Papers
Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys
Simon Badoud,Simon Borgognon,Jérôme Cottet,Pauline Chatagny,Véronique Moret,Michela Fregosi,Mélanie Kaeser,Ekaterina Fortis,Eric Schmidlin,Jocelyne Bloch,Jean-François Brunet,Eric M. Rouiller +11 more
TL;DR: The hypothesis that dlPFC contributes to predict the grip force required when a precise level of force to be generated is known beforehand is tested and the present data related to the prediction of grip force are well in line with the previous fMRI data reported for human subjects.
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Cortical Projection From the Premotor or Primary Motor Cortex to the Subthalamic Nucleus in Intact and Parkinsonian Adult Macaque Monkeys: A Pilot Tracing Study.
Simon Borgognon,Jérôme Cottet,Simon Badoud,Jocelyne Bloch,Jean-François Brunet,Eric M. Rouiller +5 more
TL;DR: Interestingly, the linear relationship between CSTP density and PD symptoms yielded a possible dependence of the CSTP re-organization with the severity of the MPTP lesion, which may be related to PD itself and/or to the ANCE treatment.
Enhancement of Striatal Dopaminergic Function Following Autologous Neural Cell Ecosystems (ANCE) Transplantation in a Non-Human Primate Model of Parkinson’s Disease
Simon Borgognon,Jérôme Cottet,Véronique Moret,Pauline Chatagny,Nathalie Ginovart,Cristian Antonescu,Jocelyne Bloch,Jean-François Brunet,Eric M. Rouiller,Simon Badoud +9 more
TL;DR: Assessing for the first time in this parkinsonian non-human primate model the striatal dopaminergic function, in parallel to further behavioral assessment, provides evidence in favor of an increase in the Striatal dopamine activity that correlates with motor recovery in this novel therapeutic approach, although the implanted cells are not dopaminaergic.
Behavioral Assessment of Manual Dexterity in Non-Human Primates
Eric Schmidlin,Mélanie Kaeser,Anne-Dominique Gindrat,Julie Savidan,Pauline Chatagny,Simon Badoud,Adjia Hamadjida,Marie-Laure Beaud,Thierry Wannier,Abderraouf Belhaj-Saïf,Eric M. Rouiller +10 more
TL;DR: Macaque monkeys are illustrated here as a suitable behavioral model to quantify manual dexterity in primates, to reflect the deficits resulting from lesion of the motor cortex or cervical cord, and measure the extent of spontaneous functional recovery and, when a treatment is applied, evaluate how much it can enhance the functional recovery.
Fine Manual Dexterity Assessment After Autologous Neural Cell Ecosystem (ANCE) Transplantation in a Non-human Primate Model of Parkinson's Disease.
Simon Borgognon,Jérôme Cottet,Véronique Moret,Pauline Chatagny,Laura Carrara,Michela Fregosi,Jocelyne Bloch,Jean-François Brunet,Eric M. Rouiller,Simon Badoud +9 more
TL;DR: The 2 manual dexterity tasks reported here as pilot are pertinent to quantify PD symptoms and reliably assess a treatment in MPTP monkeys, such as the present ANCE transplantation, to be confirmed in a larger cohort of animals before future clinical applications.