Simon Akerman
University of California, San Francisco
40 Papers
62 Citations
Simon Akerman is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Migraine & Trigeminovascular system. The author has an hindex of 25, co-authored 40 publications. Previous affiliations of Simon Akerman include University of Maryland, Baltimore & New York University.
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Papers
Pathophysiology of Migraine: A Disorder of Sensory Processing
Peter J. Goadsby,Philip R. Holland,Margarida Martins-Oliveira,Jan Hoffmann,Christoph J. Schankin,Simon Akerman +5 more
TL;DR: Investment in understanding migraine leaves us at a new dawn, able to transform its impact on a global scale, as well as understand fundamental aspects of human biology.
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Diencephalic and brainstem mechanisms in migraine
TL;DR: Dysfunction of diencephalic and brainstem nuclei that can modulate the perception of activation of the trigeminovascular system may contribute to the cascade of events that results in other symptoms of migraine — such as light and sound sensitivity — thus providing a comprehensive explanation of the neurobiology of the disorder.
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Dopamine and migraine: biology and clinical implications.
TL;DR: The literature indicates that migraineurs are hypersensitive to dopamine agonists with respect to some of the premonitory symptoms of migraine, and dopamine receptors are present in the trigeminovascular system, the area believed to be involved in headache pain, and neuronal firing here is reduced by dopamine agonist.
158
Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura.
Philip R. Holland,Simon Akerman,Anna P. Andreou,Nazia Karsan,John A. Wemmie,Peter J. Goadsby +5 more
TL;DR: Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options.
103
Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and “Triptan” Receptors: Implications in Migraine
TL;DR: It is demonstrated for the first time that brainstem endocannabinoids provide descending modulation of both basal trigeminovascular neuronal tone and Aδ-fiber dural-nociceptive responses, which differs from the way the brainstem modulates spinal nocICEptive transmission.
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