Siming Zhang
China Agricultural University
8 Papers
4 Citations
Siming Zhang is an academic researcher from China Agricultural University. The author has contributed to research in topics: Microglia & Proinflammatory cytokine. The author has an hindex of 4, co-authored 5 publications.
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Papers
CD36 Participates in PrP106–126-Induced Activation of Microglia
Mohammed Kouadir,Lifeng Yang,Rongrong Tan,Fushan Shi,Yun Lu,Siming Zhang,Xiaomin Yin,Xiangmei Zhou,Deming Zhao +8 more
TL;DR: In this paper, the role of the class B scavenger receptor CD36 in microglial activation induced by neurotoxic prion protein fragment 106-126 (PrP(106-126)).
PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia.
Siming Zhang,Lifeng Yang,Mohammed Kouadir,Rongrong Tan,Yun Lu,Jiaxin Chang,Binrui Xu,Xiaomin Yin,Xiangmei Zhou,Deming Zhao +9 more
TL;DR: It is shown that CD36 is involved in PrP106-126-induced microglial activation and that PP2 and piceatannol (Pic) can abrogate neurotoxic prion peptides-induced inducible nitric oxide synthase activation in microglia.
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Preclinical Toxicity and Immunogenicity of a COVID-19 Vaccine (ZF2001) in Cynomolgus Monkeys
Hongzhong Yang,Wei-Gang Pan,Guoyu Chen,Enqi Huang,Qijiong Lu,Yunxiang Chen,Ying Chen,Zhengbiao Yang,Lei Wen,Siming Zhang,Cong Xu,Wanqiang Lv,Lianpan Dai,Changwei Wu,Lijiang Zhang +14 more
TL;DR: ZF2001 as discussed by the authors is a recombinant protein vaccine based on SARS-CoV-2 receptor-binding domain (RBD) subunit which contains aluminum adjuvant.
Correction: CD36 Participates in PrP106–126-Induced Activation of Microglia.
Mohammed Kouadir,Lifeng Yang,Rongrong Tan,Fushan Shi,Yun Lu,Siming Zhang,Xiaomin Yin,Xiangmei Zhou,Deming Zhao +8 more
TL;DR: This work was supported by the Ministry of Agriculture, Key Program, China, and the Program for Cheung Kong Scholars and Innovative Research Team in University of China.
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Deficiency of Kif15 gene inhibits tumor growth due to host CD8+T lymphocytes increase.
Siming Zhang,Qifeng Tu,Xiaobing Qian,Junpei Wang,Chao Ma,Liu Yang,Yang Liu,Ronghua Wu,Mei Liu +8 more
TL;DR: In this paper , the effect of host Kif15 gene deficiency on tumor growth is investigated, and the results revealed that a total of 438 mRNAs were significantly differentially expressed in KIF15 knockout spleen, showing the top biological process was immune system process.
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