Simcha Yagel
University of Western Ontario
9 Papers
174 Citations
Simcha Yagel is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Cell culture & Human chorionic gonadotropin. The author has an hindex of 9, co-authored 9 publications.
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Papers
PGE2-mediated immunosuppression by first trimester human decidual cells blocks activation of maternal leukocytes in the decidua with potential anti-trophoblast activity.
TL;DR: Findings suggest that PGE2 secretion by first trimester human decidual cells blocks activation of maternal leukocytes in the decidua with potential anti-trophoblast killer function, by inhibiting IL-2 receptor generation andIL-2 production in situ.
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•Journal Article
Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells
Simcha Yagel,Alden H. Warner,Hugh N. Nellans,Peeyush K. Lala,Carol Waghorne,David T. Denhardt +5 more
TL;DR: It is suggested that the cysteine proteinases facilitate the action of metalloproteinases (collagenase, gelatinase, and stromelysin), possibly by activating them, by inactivating the tissue inhibitor of meetallop proteinases, and/or by making basement membrane matrix more accessible.
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Characterization of pure human first-trimester cytotrophoblast cells in long-term culture: growth pattern, markers, and hormone production.
TL;DR: Pure long-term cytotrophoblast cultures established from human first-trimester placentas by growing chorionic villus explants without enzymatic digestion demonstrated epithelial morphologic features and availability of pure, functionally competent human cytotrophic cells in long- term cultures is relevant for further studies in reproduction biology.
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Mechanisms of Cellular Invasiveness: A Comparison of Amnion Invasion In Vitro and Metastatic Behavior In Vivo
Simcha Yagel,Rama Khokha,David T. Denhardt,Robert S. Kerbel,Ranjit S. Parhar,Peeyush K. Lala +5 more
TL;DR: Amnion penetration provides a rigorous test for tumor cell invasiveness required for spontaneous metastasis in vivo, andInvasiveness is strongly dependent on metalloproteinase activity, which usually follows plasmin activation.
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Trophic effects of first-trimester human trophoblasts and human chorionic gonadotropin on lymphocyte proliferation.
TL;DR: Trophoblast or trophoblast-derived human chorionic gonadotropin has a lymphocytotrophic function that may have implications for fetal survival and is examined in a dose-dependent manner.
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