Simcha Milo
3 Papers
Simcha Milo is an academic researcher. The author has contributed to research in topics: Arginine & Oxysterol. The author has an hindex of 3, co-authored 3 publications.
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Papers
Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient transgenic mice and in humans is oxidized and aggregated.
Michael Aviram,Irit Maor,Shlomo Keidar,Tony Hayek,J. Oiknine,Yaron Bar-El,Zvi Adler,Victor Kertzman,Simcha Milo +8 more
TL;DR: Both oxidation and aggregation of lesioned LDL could be the result of aortic lesioned-induced modification of the lipoprotein, and both of these modified forms of LDL can further contribute to the acceleration of the atherosclerotic process.
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Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins
TL;DR: In human coronary and carotid lesions, obtained from endatherectomic samples, 27-hydroxycholesterol (27-OH) was the major oxysterol, with about 85% as sterols esterified to fatty acids, and this finding may indicate that such an enzymatic process does not take place in E° mice.
Human Serum Paraoxonases (PON1) Q and R Selectively Decrease Lipid Peroxides in Human Coronary and Carotid Atherosclerotic Lesions PON1 Esterase and Peroxidase-Like Activities
Michael Aviram,Emiliya Hardak,Jacob Vaya,Saeed Mahmood,Simcha Milo,Aaron Hoffman,Scott Billicke,Dragomir I. Draganov,Mira Rosenblat +8 more
TL;DR: It is concluded that PON1 may be antiatherogenic because it hydrolyzes lipid peroxides in human atherosclerotic lesions and demonstrates esterase- like and peroxidase-like activities.