Simanta Pathak
University of Texas Southwestern Medical Center
12 Papers
2 Citations
Simanta Pathak is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Systemic lupus erythematosus & B cell. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Simanta Pathak include University of Nebraska Medical Center & University of Houston.
Chat about Author
Papers
IRF4 is a suppressor of c-Myc induced B cell leukemia.
Simanta Pathak,Shibin Ma,Long Trinh,James D. Eudy,Kay Uwe Wagner,Shantaram S. Joshi,Runqing Lu +6 more
TL;DR: Interferon regulatory factor 4 functions as a classical tumor suppressor to inhibit c-Myc induced B cell leukemia in EμMyc mice.
Prevention of Murine Lupus Nephritis by Targeting Multiple Signaling Axes and Oxidative Stress Using a Synthetic Triterpenoid
Tianfu Wu,Yujin Ye,So Youn Min,Jiankun Zhu,Elhaum Khobahy,Jason K. Zhou,Mei Yan,Sriram Hemachandran,Simanta Pathak,Xin J. Zhou,Michael Andreeff,Chandra Mohan +11 more
TL;DR: The synthetic triterpenoid methyl‐2‐cyano‐3,12‐dioxooleana‐1,9‐dien‐28‐oate (CDDO‐Me) has been shown to inhibit AKT, MEK‐1/2, and NF‐κB, and to induce caspase‐mediated apoptosis, and the therapeutic potential of this agent was tested in murine lupus nephritis.
44
Murine lupus strains differentially model unique facets of human lupus serology
Li Li,S. Nukala,Yong Du,Jie Han,K. Liu,Jack Hutcheson,Simanta Pathak,Quan Zhen Li,Chandra Mohan +8 more
TL;DR: Just as in patients with SLE, whereas strong IgG reactivity to nuclear antigens is associated with severe renal disease, a polyreactive IgM seroprofile is also less ominous in murine lupus.
21
Targeting Multiple End Organs in Lupus and Other Systemic Rheumatic Diseases by Inhibiting Bruton’s Tyrosine Kinase
Yong Du,Ling Lei,Huihua Ding,Yanping Chen,Simanta Pathak,John Hicks,Phuong-Thao Tran,Minghua Wu,Betty Y. Chang,Uwe Wirtz,Chandra Mohan +10 more
TL;DR: This study provides the first evidence that BTK inhibition has both therapeutic and preventative effects in bleomycin-induced SSc-like disease, in terms of reducing skin thickness, fibrosis, collagen deposition, and inflammation.
6
•Journal Article
BANK1 transgenic mice exhibit lupus-associated B cell phenotypes (BA3P.105)
Simanta Pathak,Yuyuan Guo,Huihua Ding,Yong Du,So Youn Min,Kamala Vanarsa,Quan Zhen Li,Sergey V. Kozyrev,Marta E. Alarcón-Riquelme,Chandra Mohan +9 more
TL;DR: These studies indicate that the different isoforms of BANK1 observed in humans contribute differentially to the development of B-cell autoimmunity.
1