Silvia Valtorta
University of Milan
37 Papers
88 Citations
Silvia Valtorta is an academic researcher from University of Milan. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 13, co-authored 31 publications. Previous affiliations of Silvia Valtorta include Vita-Salute San Raffaele University & University of Milano-Bicocca.
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Papers
Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models.
Silvia Valtorta,Alessia Lo Dico,Isabella Raccagni,Daniela Gaglio,Sara Belloli,Letterio S. Politi,Letterio S. Politi,Cristina Martelli,Cecilia Diceglie,Marcella Bonanomi,Giulia Ercoli,Valentina Vaira,Valentina Vaira,Luisa Ottobrini,Rosa Maria Moresco +14 more
TL;DR: Results showed that metformin is able to enhance TMZ effect in TMZ-resistant cell line suggesting its potential use in TMZ refractory GBM patients, however, the lack of effect on a GBM malignancy marker like CD133 requires further evaluation.
VEGF-Targeted Therapy Stably Modulates the Glycolytic Phenotype of Tumor Cells
Matteo Curtarello,Elisabetta Zulato,Giorgia Nardo,Silvia Valtorta,Giulia Guzzo,Elisabetta Rossi,Giovanni Esposito,Aichi Msaki,Anna Pastò,Andrea Rasola,Luca Persano,Francesco Ciccarese,Roberta Bertorelle,Sergio Todde,Mario Plebani,Henrike Schroer,Stefan Walenta,Wolfgang Mueller-Klieser,Alberto Amadori,Rosa Maria Moresco,Stefano Indraccolo +20 more
TL;DR: The results support the hypothesis that the highly glycolytic phenotype of tumor cells studied in xenograft models, either primary or secondary, is a cell-autonomous trait conferring resistance to VEGF blockade.
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Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells.
Rosanna Mezzapelle,Eltjona Rrapaj,Elena Gatti,Chiara Ceriotti,Francesco De Marchis,Alessandro Preti,Antonello E. Spinelli,Laura Perani,Massimo Venturini,Silvia Valtorta,Rosa Maria Moresco,Rosa Maria Moresco,Lorenza Pecciarini,Claudio Doglioni,Michela Frenquelli,Luca Crippa,Camilla Recordati,Eugenio Scanziani,Hilda de Vries,Anton Berns,Roberta Frapolli,Renzo Boldorini,Maurizio D'Incalci,Marco Bianchi,Massimo P. Crippa +24 more
TL;DR: The molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice is described, which allows the study of the interplay of tumor cells with the immune system.
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The peritumoral brain zone in glioblastoma: where we are and where we are going
Martina Giambra,Andrea Di Cristofori,Silvia Valtorta,Roberto Manfrellotti,Vittorio Bigiogera,Gianpaolo Basso,Rosa Maria Moresco,Carlo Giussani,Angela Bentivegna +8 more
TL;DR: The aim of this review is to provide up-to-date knowledge about the oncogenic properties of the PBZ to highlight possible druggable targets for more effective treatment of GBM by limiting the formation of recurrence, which is almost inevitable in the majority of patients.
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Comparison of 18F-Fluoroazomycin-Arabinofuranoside and 64Cu-Diacetyl-Bis(N4-Methylthiosemicarbazone) in Preclinical Models of Cancer
Silvia Valtorta,Sara Belloli,Francesca Sanvito,Valeria Masiello,Giuseppe Di Grigoli,Cristina Monterisi,Ferruccio Fazio,Maria Picchio,Rosa Maria Moresco +8 more
TL;DR: The results of this study confirm the cell-dependent distribution and retention kinetics of 64Cu-ATSM and underline the need for proper validation of animal models and PET acquisition protocols before exploration of any new clinical applications.
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