Silvia Pace
Sigma-Tau
25 Papers
213 Citations
Silvia Pace is an academic researcher from Sigma-Tau. The author has contributed to research in topics: Piperaquine & Pharmacokinetics. The author has an hindex of 12, co-authored 25 publications.
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Papers
Phase I study of the heparanase inhibitor roneparstat: an innovative approach for ultiple myeloma therapy.
Monica Galli,Manik Chatterjee,Mariella Grasso,Giorgina Specchia,Hila Magen,Hermann Einsele,Ivana Celeghini,Paola Barbieri,David Paoletti,Silvia Pace,Ralph D. Sanderson,Alessandro Rambaldi,Arnon Nagler +12 more
TL;DR: The role that the bone marrow microenvironment plays in differentiation, migration, proliferation, survival and drug resistance of malignant plasma cells has attracted significant attention in the attempt to identify new druggable targets in multiple myeloma.
•Journal Article
Potent Antitumor Activity and Improved Pharmacological Profile of ST1481, a Novel 7-substituted Camptothecin
Michelandrea De Cesare,Graziella Pratesi,Paola Perego,Nives Carenini,Stella Tinelli,Lucio Merlini,Sergio Penco,Claudio Pisano,Federica Bucci,Loredana Vesci,Silvia Pace,Francesca Capocasa,Paolo Carminati,Franco Zunino +13 more
TL;DR: The results support the hypothesis that a potent lipophilic camptothecin with a proper substituent at the position 7 may have therapeutic advantages likely related to a rapid intracellular uptake and tissue distribution, stabilization of the drug-target complex, and good oral bioavailability.
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In Vitro Cardiovascular Effects of Dihydroartemisin-Piperaquine Combination Compared with Other Antimalarials
Franco Borsini,William Crumb,Silvia Pace,David Ubben,Barb Wible,Gan-Xin Yan,Christian Funck-Brentano +6 more
TL;DR: Despite significant hERG blockade, DHA-PQP and artemether-lumefantrine do not appear to induce potential torsadogenic effects in vitro, affect hERG trafficking, or block sodium and slow potassium ion current interference.
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Evaluation of a new biotin-DOTA conjugate for pretargeted antibody-guided radioimmunotherapy (PAGRIT ® )
Nicoletta Urbano,Stefano Papi,Mauro Ginanneschi,Rita De Santis,Silvia Pace,Ragnar Lindstedt,Liliana Ferrari,SunJu Choi,Giovanni Paganelli,Marco Chinol +9 more
TL;DR: The structural modifications proposed for the r-BHD stabilised it against enzymatic degradation while retaining high binding affinity for avidin, indicating that the new biotin-DOTA conjugate may be a suitable candidate for pretargeting trials.
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Propionyl-L-Carnitine is Efficacious in Ulcerative Colitis Through its Action on the Immune Function and Microvasculature.
Maria Giovanna Scioli,Maria Antonietta Stasi,Daniela Passeri,Elena Doldo,Gaetana Costanza,Roberto Camerini,Paolo Fociani,Gaetano Arcuri,Katia Lombardo,Silvia Pace,Franco Borsini,Augusto Orlandi +11 more
TL;DR: The results show that the beneficial antioxidant effect of PLC targeting intestinal microvasculature restores endothelial β-oxidation and function, and reduces mucosal inflammation in UC patients.
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