Silvia Massari
University of Milan
8 Papers
94 Citations
Silvia Massari is an academic researcher from University of Milan. The author has contributed to research in topics: PDZ domain & Transporter. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Silvia Massari include Yale University.
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Papers
Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS)
C. Vanoni,Silvia Massari,Marco Losa,Paolo Carrega,Carla Perego,Laura Conforti,Grazia Pietrini +6 more
TL;DR: The data indicate that the continuous expression of mutant SOD1 causes the downregulation of GLT-1 by increasing the internalisation and degradation of the surface transporter, and suggest that the cytosolic tail of GLt-1 is required to target the transporter to degradation.
LIN7 mediates the recruitment of IRSp53 to tight junctions.
Silvia Massari,Carla Perego,Valeria Padovano,Anna D’Amico,Andrea Raimondi,Maura Francolini,Grazia Pietrini +6 more
TL;DR: LIN7–IRSp53 association plays a role during assembly of functional TJs and surface polarization in epithelial cells, indicating that LIN7– IRSp53 associations play a role in tight junction assembly in Madin–Darby canine kidney cells.
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Protein Kinase C-mediated Phosphorylation of the BGT1 Epithelial γ-Aminobutyric Acid Transporter Regulates Its Association with LIN7 PDZ Proteins A POST-TRANSLATIONAL MECHANISM REGULATING TRANSPORTER SURFACE DENSITY
TL;DR: In this article, a protein kinase C (PKC)-mediated mechanism regulating the association between BGT1 and LIN7 was described, where reduced transport activity paralleled by the intracellular relocalization of the transporter was observed in response to the PKC activation induced by 12-Otetradecanoylphorbol-13-acetate (TPA) treatment.
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PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells.
TL;DR: It is shown that stimulation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) treatment induces a time-dependent decrease in glutamate transport activity due to relocalization of the excitatory amino acid carrier 1 (EAAC1) glutamate transporter from the apical surface of polarized epithelial Madin-Darby canine kidney cells to intracellular compartments.
12
Cell culture models to investigate the selective vulnerability of motoneuronal mitochondria to familial ALS-linked G93ASOD1.
Andrea Raimondi,Alessandra Mangolini,M. Rizzardini,Silvia Tartari,Silvia Massari,Caterina Bendotti,Maura Francolini,Nica Borgese,Lavinia Cantoni,Grazia Pietrini +9 more
TL;DR: The results suggest that mitochondrial vulnerability of motoneurons to G93ASOD1 is recapitulated in NSC‐34 cells, and that peculiar features in network dynamics may account for the selective alterations of mot oneuronal mitochondria.