Silke Eble
University of Freiburg
4 Papers
Silke Eble is an academic researcher from University of Freiburg. The author has contributed to research in topics: Potassium channel & SK channel. The author has an hindex of 4, co-authored 4 publications.
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Papers
BKCa-Cav Channel Complexes Mediate Rapid and Localized Ca2+-Activated K+ Signaling
Henrike Berkefeld,Claudia A. Sailer,Wolfgang Bildl,Volker Rohde,Jörg-Oliver Thumfart,Silke Eble,Norbert Klugbauer,Ellen Reisinger,Josef Bischofberger,Dominik Oliver,Hans-Günther Knaus,Uwe Schulte,Bernd Fakler +12 more
TL;DR: Heterologously expressed BKCa-Cav complexes reconstitute a functional “Ca2+ nanodomain” where Ca2+ influx through the Cav channel activates BK Ca in the physiological voltage range with submillisecond kinetics, enabling BkCa-mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system.
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The Epilepsy-Linked Lgi1 Protein Assembles into Presynaptic Kv1 Channels and Inhibits Inactivation by Kvβ1
Uwe Schulte,Jörg-Oliver Thumfart,Nikolaj Klöcker,Claudia A. Sailer,Wolfgang Bildl,Martin L. Biniossek,Doris Dehn,Thomas Deller,Silke Eble,Karen Abbass,Tanja Wangler,Hans-Günther Knaus,Bernd Fakler +12 more
TL;DR: The results establish Lgi1 as a novel subunit of Kv1.1-associated protein complexes and suggest that changes in inactivation gating of presynaptic A-type channels may promote epileptic activity.
Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating.
Wolfgang Bildl,Tim Strassmaier,Henrike Thurm,Jens S. Andersen,Silke Eble,Dominik Oliver,Marlies Knipper,Matthias Mann,Uwe Schulte,John P. Adelman,Bernd Fakler +10 more
TL;DR: The results show that native SK channels are polyprotein complexes and demonstrate that the balance between kinase and phosphatase activities within the protein complex shapes the hyperpolarizing response mediated by SK channels.
BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling
Henrike Berkefeld,Claudia A. Sailer,Wolfgang Bildl,Volker Rohde,Jörg-Oliver Thumfart,Silke Eble,Norbert Klugbauer,Ellen Reisinger,Josef Bischofberger,Dominik Oliver,Hans-Günther Knaus,Uwe Schulte,Bernd Fakler +12 more
TL;DR: In this article, large-conductance calcium and voltage-activated potassium channels (BKCa) are assembled into macromolecular complexes with the voltage-gated calcium channels Cav1.2 (L-type), Cav2.1 (P/Q-type) and Cav 2.2(N-type).