Siham Boukour
Institut Gustave Roussy
14 Papers
159 Citations
Siham Boukour is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Cellular differentiation & Thrombopoiesis. The author has an hindex of 12, co-authored 14 publications. Previous affiliations of Siham Boukour include French Institute of Health and Medical Research & University of Paris-Sud.
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Papers
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.
Laure Gilles,Laure Gilles,Laure Gilles,Dominique Bluteau,Dominique Bluteau,Dominique Bluteau,Siham Boukour,Siham Boukour,Siham Boukour,Yunhua Chang,Yunhua Chang,Yunhua Chang,Yanyan Zhang,Yanyan Zhang,Yanyan Zhang,Thomas Robert,Thomas Robert,Philippe Dessen,Philippe Dessen,Philippe Dessen,Najet Debili,Najet Debili,Najet Debili,Olivier Bernard,William Vainchenker,William Vainchenker,William Vainchenker,Hana Raslova,Hana Raslova,Hana Raslova +29 more
TL;DR: It is shown that MAL expression increases during the late differentiation steps of neonate and adult human megakaryopoiesis and localized into the nucleus after Rho GTPase activation by adhesion on collagen I or convulxin and MAL/SRF complex is involved in platelet formation andmegakaryocyte migration by regulating MYL9 and MMP9.
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Platelet interaction with bacteria.
TL;DR: Platelets exert their main function in hemostasis and thrombosis, but they also are able to internalise infectious particles such as bacteria and viruses as well as inert particles like latex beads, which could confer to platelets a role in the protection and defense of the organism against any invasion by micro-organisms.
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The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.
Yolande Chen,Yolande Chen,Siham Boukour,Siham Boukour,Rachel Milloud,Rémi Favier,Rémi Favier,B Saposnik,N. Schlégel,Alan T. Nurden,Hana Raslova,Hana Raslova,William Vainchenker,William Vainchenker,Martial Balland,Paquita Nurden,Najet Debili,Najet Debili +17 more
TL;DR: Mutations in the MYH9 gene cause autosomal dominant MYH 9‐related diseases (MYH9‐RD) that associate macrothrombocytopenia with various other clinical conditions and the mechanisms giving rise to giant platelets remain poorly understood.
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Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.
Ashfaq Ali,Olivier Bluteau,Olivier Bluteau,Olivier Bluteau,Kahia Messaoudi,Kahia Messaoudi,Kahia Messaoudi,Alberta Palazzo,Alberta Palazzo,Alberta Palazzo,Siham Boukour,Siham Boukour,Siham Boukour,Larissa Lordier,Larissa Lordier,Larissa Lordier,Yann Lécluse,Philippe Rameau,L Kraus-Berthier,A Jacquet-Bescond,H Lelièvre,S Depil,Philippe Dessen,Eric Solary,Eric Solary,Eric Solary,Hana Raslova,Hana Raslova,Hana Raslova,William Vainchenker,William Vainchenker,William Vainchenker,Isabelle Plo,Isabelle Plo,Isabelle Plo,Najet Debili,Najet Debili,Najet Debili +37 more
TL;DR: The results suggest that HDACi induces a thrombocytopenia by a p53-dependent mechanism along MK differentiation and a p 53-dependent and -independent mechanism for PPT formation.
An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.
Fabrizia Favale,Kahia Messaoudi,Kahia Messaoudi,Leila N. Varghese,Leila N. Varghese,Siham Boukour,Siham Boukour,Christian Pecquet,Christian Pecquet,Vitalina Gryshkova,Vitalina Gryshkova,Jean-Philippe Defour,Jean-Philippe Defour,Roxana-Irina Albu,Roxana-Irina Albu,Olivier Bluteau,Olivier Bluteau,Paola Ballerini,Guy Leverger,Isabelle Plo,Isabelle Plo,Najet Debili,Najet Debili,Hana Raslova,Hana Raslova,Rémi Favier,Stefan N. Constantinescu,Stefan N. Constantinescu,William Vainchenker,William Vainchenker +29 more
TL;DR: It is demonstrated that MPL P106L is a receptor with an incomplete defect in trafficking, which induces a low but not absent localization of the receptor on cell surface and a response to THPO in immature MK cells.
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