Sigrun R. Hofmann
Dresden University of Technology
44 Papers
149 Citations
Sigrun R. Hofmann is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Chronic recurrent multifocal osteomyelitis & Inflammation. The author has an hindex of 21, co-authored 38 publications. Previous affiliations of Sigrun R. Hofmann include National Institutes of Health & Boston Children's Hospital.
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Papers
DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis.
Valentina Natoli,Amandine Charras,Sigrun R. Hofmann,Sarah Northey,Susanne Ruß,Felix Schulze,Liza J McCann,Susanne Abraham,Christian M. Hedrich +8 more
TL;DR: DNA methylation profiles in CD4+ T-cells discriminate between skin psoriasis and PsA patients, and DNA methylation signatures may be applied for quantification of disease activity and patient stratification towards individualized treatment.
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Agenesis of the ductus venosus—A case with favorable outcome after early signs of cardiac failure
TL;DR: A patient is reported with ADV and extrahepatic umbilical vein drainage with favorable outcome after intrauterine reversal of early signs of cardiac failure and ultrasound imaging of the venous duct should be considered in the case of cardiomegaly with or without further signs of heart failure.
7
Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis.
Sigrun R. Hofmann,Emil Carlsson,Franz Kapplusch,Ana L Carvalho,Triantafillos Liloglou,Felix Schulze,Susanne Abraham,Sarah Northey,Susanne Russ,Anna Elisa Andrea Surace,Nobuya Yoshida,George C. Tsokos,Christian M. Hedrich,Christian M. Hedrich,Christian M. Hedrich +14 more
TL;DR: In this article, the authors show that CD4+ T cells from patients with psoriasis and psoriatic arthritis exhibit increased production of IL-17 but decreased expression of IL 2 and PD-1.
5
Recent Advances in Autoinflammatory Diseases and Animal Models
TL;DR: Recent advances in the understanding of the pathogenesis of autoinflammatory diseases are summarized and selected mouse models available to study such diseases are reviewed.
5
678 Damaging variants in P2X7R associate with Chronic Nonbacterial Osteomyelitis (CNO)
Amandine Charras,Sigrun R. Hofmann,Allison Cox,Felix Schulze,Susanne Ruß,Hella Hartmann,Sam Haldenby,Xuan Liu,Henner Morbach,Helmut Wittkowski,Polly J. Ferguson,Christian M. Hedrich +11 more
TL;DR: In this paper , the authors used whole exome sequencing in families with chronic nonbacterial osteomyelitis (CNO) and target sequencing of P2X7R in a large German CNO cohort.