5 Papers
Siegrid Damsch is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Gastric emptying & Medicine. The author has an hindex of 4, co-authored 5 publications.
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Papers
Gavage-Related Reflux in Rats Identification, Pathogenesis, and Toxicological Implications (Review)
Siegrid Damsch,Gary Eichenbaum,Alfred Tonelli,L. Lammens,Kathleen Van den Bulck,Bianca Feyen,John Vandenberghe,Anton Megens,Elaine Knight,Kelley Michael F +9 more
TL;DR: The article aims to increase the awareness and understanding of the pathogenesis of gavage-related reflux and provides guidance on identification of potential risk factors, as well as interpretation of histological changes and their toxicological relevance.
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Phospholipidosis in Rats Treated with Amiodarone: Serum Biochemistry and Whole Genome Micro-Array Analysis Supporting the Lipid Traffic Jam Hypothesis and the Subsequent Rise of the Biomarker BMP
Natalie Mesens,Miek Desmidt,Geert R. Verheyen,Sofie Starckx,Siegrid Damsch,Ronald De Vries,Marc Verhemeldonck,Jacky Van Gompel,Ann Lampo,Lieve Lammens +9 more
TL;DR: Modulation indicates that during phospholipidosis-induction interactions take place between the cationic amphiphilic drug andospholipids at the level of BMP-rich internal membranes of endosomes, impeding cholesterol sorting and leading to an accumulation of internal membranes, converting into multilamellar bodies.
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Impact of gavage dosing procedure and gastric content on adverse respiratory effects and mortality in rat toxicity studies
Gary Eichenbaum,Siegrid Damsch,Adriana Looszova,John Vandenberghe,K. Van den Bulck,Karen Roels,Anton Megens,Elaine Knight,V. Hillsamer,Bianca Feyen,Kelley Michael F,Alfred Tonelli,L. Lammens +12 more
TL;DR: Reducing the dose volume and dosing fasted animals substantially reduced or eliminated the respiratory effects and mortality at the high test article concentrations, demonstrating that the adverse effects are related to the gavage method.
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Unexpected Nasal Changes in Rats Related to Reflux after Gavage Dosing
Siegrid Damsch,Gary Eichenbaum,Adriana Looszova,L. Lammens,Bianca Feyen,Kathleen Van den Bulck,Elaine Knight,Kelley Michael F,Alfred Tonelli +8 more
TL;DR: The current article focuses on the histological changes in the nasal cavity indicative of gavage-related reflux and provides guidance on differentiation between technical gavage error and g Savage- related reflux.
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emptying: potential role of vagal inhibition Pramlintide, an amylin analog, selectively delays gastric
Lawrence A. Szarka,Adrian Vella,R Alan,Bianca Feyen,J. Vandenberghe,Anton Megens,Elaine Knight,Kelley Michael F,Siegrid Damsch,Gary Eichenbaum,Alfred Tonelli,Lieve Lammens,Kathleen Van den Bulck +12 more
- 01 Jan 2011