Sidra M. Hoffman
University of Vermont
22 Papers
121 Citations
Sidra M. Hoffman is an academic researcher from University of Vermont. The author has contributed to research in topics: House dust mite & Inflammation. The author has an hindex of 18, co-authored 22 publications.
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Papers
JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers
Jos van der Velden,Ying Ye,James D. Nolin,Sidra M. Hoffman,David G. Chapman,Karolyn G. Lahue,Sarah Abdalla,Peng Chen,Yong Liu,Brydon L. Bennett,Nasreen Khalil,Donna Sutherland,William T. Smith,Gerald Horan,Mahmoud Assaf,Zebulun Horowitz,Rajesh Chopra,R. Stevens,Maria Palmisano,Yvonne M. W. Janssen-Heininger,Peter H. Schafer +20 more
TL;DR: Results illustrate JNK enzymatic activity involvement during pulmonary fibrosis, and support systemic biomarker use for tracking disease progression and the potential clinical benefit of this novel intervention in IPF.
Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis
Sidra M. Hoffman,Jane E. Tully,James D. Nolin,Karolyn G. Lahue,Dylan Goldman,Nirav Daphtary,Minara Aliyeva,Charles G. Irvin,Anne E. Dixon,Matthew E. Poynter,Vikas Anathy +10 more
TL;DR: It is indicated that HDM induces ER stress in airway epithelial cells and that ATF6α and ERp57 play a significant role in the development of cardinal features of allergic airways disease.
Epithelial NF-κB Orchestrates House Dust Mite–Induced Airway Inflammation, Hyperresponsiveness, and Fibrotic Remodeling
Jane E. Tully,Sidra M. Hoffman,Karolyn G. Lahue,James D. Nolin,Vikas Anathy,Lennart K. A. Lundblad,Nirav Daphtary,Minara Aliyeva,Kendall E. Black,Anne E. Dixon,Matthew E. Poynter,Charles G. Irvin,Yvonne M. W. Janssen-Heininger +12 more
TL;DR: It is demonstrated that following airway exposure with an asthma-relevant allergen, activation of classical and alternative NF-κB pathways occurs within the airway epithelium and may coordinately contribute to allergic inflammation, AHR, and fibrotic airway remodeling.
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Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells.
Jane T. Jones,Xi Qian,Jos van der Velden,Shi Biao Chia,David H. McMillan,Stevenson Flemer,Sidra M. Hoffman,Karolyn G. Lahue,Robert W. Schneider,James D. Nolin,Vikas Anathy,Albert van der Vliet,Danyelle M. Townsend,Kenneth D. Tew,Yvonne M. W. Janssen-Heininger +14 more
TL;DR: It is demonstrated that, in unstimulated cells, GSTP associated with the inhibitor of NF-κB, IκBα, and that targeting GSTP is a potential avenue for regulating the activity of this prominent pro-inflammatory and immunomodulatory transcription factor.
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Oxidative Processing of Latent Fas in the Endoplasmic Reticulum Controls the Strength of Apoptosis
Vikas Anathy,Elle C. Roberson,Brian Cunniff,James D. Nolin,Sidra M. Hoffman,Page C. Spiess,Amy S. Guala,Karolyn G. Lahue,Dylan Goldman,Stevenson Flemer,Albert van der Vliet,Nicholas H. Heintz,Ralph C. Budd,Kenneth D. Tew,Yvonne M. W. Janssen-Heininger +14 more
TL;DR: Findings illuminate a regulatory switch, a ligand-initiated oxidative processing of latent Fas, that controls the strength of apoptosis.
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