5 Papers
Si-qi Ma is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Leber's hereditary optic neuropathy. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Si-qi Ma include Hubei University of Medicine.
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Papers
Efficacy and Safety of rAAV2-ND4 Treatment for Leber’s Hereditary Optic Neuropathy
Xing Wan,Han Pei,Min-jian Zhao,Shuo Yang,Weikun Hu,Heng He,Si-qi Ma,Ge Zhang,Xiao-yan Dong,Chen Chen,Dao Wen Wang,Bin Li +11 more
TL;DR: Findings support the feasible use of gene therapy for LHON by evaluating the efficacy and safety of a recombinant adeno-associated virus 2 carrying ND4 (rAAV2-ND4) in LHON patients carrying the G11778A mutation.
Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy.
Shuo Yang,Si-qi Ma,Xing Wan,Heng He,Han Pei,Min-jian Zhao,Chen Chen,Dao Wen Wang,Xiao-yan Dong,Jiajia Yuan,Bin Li +10 more
TL;DR: The results support the use of intravitreal rAAV2-ND4 as an aggressive maneuver in the clinical trial and further study in additional patients and in these 9 subjects is needed to better understand the effects of rAAv2- ND4 gene therapy on LHON and to increase the applications of this technique.
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Evaluation of Leber's hereditary optic neuropathy patients prior to a gene therapy clinical trial.
TL;DR: The effects of Leber hereditary optical neuropathy (LHON) gene therapy should be evaluated primarily based on visual acuity, and visual field, neural fiber thickness, and electrophysiology should be considered in the evaluation.
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Visual Field Variability after Gene Therapy for Leber's Hereditary Optic Neuropathy
Jiajia Yuan,Jiajia Yuan,Yong Zhang,Li-Ling Wang,Ming-Shi Cheng,Si-qi Ma,Si-qi Ma,Qin Gao,Bin Li,Bin Li +9 more
TL;DR: It is suggested that monocular intravitreal injection of AAV2-ND4 can improve binocular VF values, and this study suggests that gene therapy can be effective in patients with a disease duration of > 2 years.
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Multilocus Mitochondrial Mutations Do Not Directly Affect the Efficacy of Gene Therapy for Leber Hereditary Optic Neuropathy.
TL;DR: Investigating whether multilocus mitochondrial mutations directly influence the efficacy of gene therapy for Leber hereditary optic neuropathy found detection of the 3 primary mitochondrial mutations causing LHON is sufficient for screening before gene therapy; sequencing of the entire mitochondrial genome is unnecessary before treatment.
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