7 Papers
Si Chen is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Copy-number variation & Cancer. The author has an hindex of 2, co-authored 5 publications.
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Papers
AluScanCNV2: An R package for copy number variation calling and cancer risk prediction with next-generation sequencing data.
TL;DR: An AlUScanCNV2 software has been developed in the present study as an R package that performs CNV detection from NGS data obtained through AluScan, whole-genome sequencing or other targeted NGS platforms.
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Copy number variation profile-based genomic typing of premenstrual dysphoric disorder in Chinese
Hong Xue,Zhenggang Wu,Xi Long,Ata Ullah,Si Chen,Wai-Kin Mat,Peng Sun,Mingzhou Gao,Wang Jieqiong,Wang Haijun,Xia Li,Wenjun Sun,Mingqi Qiao +12 more
TL;DR: In this article, the analysis of genomic sequencing-based copy-number-variations (CNVs) called from 100-kb white blood cell DNA sequence windows by means of semi-supervised clustering led to the segregation of patient genomes into the D and V groups, which correlated with the depression and invasion clinical types respectively with 89.0% consistency.
Copy number variation profile-based genomic subtyping of premenstrual dysphoric disorder in Chinese
Hong Xue,Hong Xue,Hong Xue,Zhenggang Wu,Zhenggang Wu,Xi Long,Ata Ullah,Si Chen,Wai-Kin Mat,Peng Sun,Mingzhou Gao,Wang Jieqiong,Wang Haijun,Xia Li,Wenjun Sun,Mingqi Qiao +15 more
TL;DR: Wang et al. as mentioned in this paper used correlation-and frequency-based CNV features of either CNVgain (CNVG) or CNV-loss (cNVL) that could differentiate between V and D subtypes of premenstrual dysphoric disorder (PMDD).
AluScan sequencing and its application to cancer genomics
Ganbolor Sukhbaatar,Si Chen,Wai-Kin Mat,Hong Xue +3 more
TL;DR: In this paper , the authors examined how the AluScan platform could be employed to analyze the somatic and germline single-nucleotide-variations (SNVs) and copy-number-variation (CNVs) related to cancers, in order to delineate some of the occurences and concequences of such mutations.
Forward and reverse mutations in stages of cancer development.
Taobo Hu,Yogesh Kumar,Iram shazia,Shen-Jia Duan,Yi Li,Lei Chen,Jin-Fei Chen,Rong Yin,Ava Kwong,Gilberto K.K. Leung,Wai-Kin Mat,Zhenggang Wu,Xi Long,Cheuk Hin Chan,Si Chen,Peggy Lee,Siu Kin Ng,Timothy Y. C. Ho,Jianfeng Yang,Xiaofan Ding,Shui Ying Tsang,Xuqing Zhou,Dan-Hua Zhang,En-Xiang Zhou,Lin Xu,Wai Sang Poon,Hongyang Wang,Hong Xue,Hong Xue +28 more
TL;DR: These findings suggest that developing cancer cells undergo sequential changes that enable the ‘nontumor’ cells to acquire a wide range of forward mutations including ones that are essential for oncogenicity, followed by revertant mutations in the “paratumor” cells to avoid growth retardation by excessive mutation load.