Shuting Chen

TL;DR: Mapping of the 5'LS tags on the genome not only provided direct evidence of expression for in silico predicted genes but also allowed for the identification of previously unrecognized, novel exons and alternative TSSs.

TL;DR: The functional analyses of PRPS1 mutants uncovered a new chemotherapy-resistance mechanism involving reduced feedback inhibition of de novo purine biosynthesis and competitive inhibition of thiopurine activation, and the de noVO purine synthesis inhibitor lometrexol effectively abrogatedPRPS1 mutant–driven drug resistance.

TL;DR: The sequenced G. barbadense genome advances the understanding of allopolyploidy, which will help improve cotton fiber quality and the rapid diversification of sesquiterpene synthase genes in the gossypol pathway exemplifies the chemical diversity of lineage-specific secondary metabolites.

TL;DR: This study uncovers the mutation spectrum of air pollution-related lung cancers, and provides evidence for pollution exposure–genomic mutation relationship at a large scale.