Shuko Lee
Murphy Oil
11 Papers
30 Citations
Shuko Lee is an academic researcher from Murphy Oil. The author has contributed to research in topics: Calorie restriction & Oxidative stress. The author has an hindex of 11, co-authored 11 publications. Previous affiliations of Shuko Lee include Veterans Health Administration.
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Papers
Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity
TL;DR: It is found that the incidence of presumably fatal adenocarcinoma in lung was significantly lower in Ames dwarf mice than for their normal siblings and possibly could be attributed to the retardation of tumor development by changes in the levels of growth hormone and insulin-like growth factor-1, and thereby be a major contributing factor to the extended life span observed in these mice.
Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice
Yuji Ikeno,Gene B. Hubbard,Shuko Lee,Lisa A. Cortez,Christie M. Lew,Celeste R. Webb,Darlene E. Berryman,Edward O. List,John J. Kopchick,Andrzej Bartke +9 more
TL;DR: In this paper, the authors found that growth hormone receptor/binding protein (GHR/BP) knockout mice have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates.
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress.
Holly Van Remmen,Wenbo Qi,Marian Sabia,Gregory Freeman,Gregory Freeman,Larry Estlack,Hong Yang,Zhong Mao Guo,Ting-Ting Huang,Randy Strong,Shuko Lee,Charles J. Epstein,Arlan Richardson +12 more
TL;DR: Sod2(+/-)/Gpx1(-/-) mice, deficient in two mitochondrial antioxidant enzymes, have significantly enhanced sensitivity to oxidative stress induced by exogenous insults and to endogenous oxidative stress compared with either wild-type mice or mice deficient in either MnSOD or Gpx1 alone.
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Housing Density Does Not Influence the Longevity Effect of Calorie Restriction
Yuji Ikeno,Gene B. Hubbard,Shuko Lee,Arlan Richardson,Arlan Richardson,Randy Strong,Vivian Diaz,James F. Nelson +7 more
TL;DR: It is indicated that CR can extend life span as effectively in multiply as in singly housed mice, even though housing density can differentially affect the cancer-reducing effect of CR.
Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?
Yuji Ikeno,Gene B. Hubbard,Shuko Lee,Sara Dube,Lisa C. Flores,Madeline G. Roman,Andrzej Bartke +6 more
- 20 Jun 2013
TL;DR: The findings show that the changes in age-related diseases between AL-fed Ames dwarf mice and CR wild-type siblings were similar but not identical, indicating that calorie restriction and Ames dwar mice exhibit their anti-aging effects through both independent and common mechanisms.
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